Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Homocysteine"”.
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Role of Betaine-Homocysteine S-Methyltransferase in Homocysteine Methylation
… To address whether BHMT inhibition caused hyperhomocysteinemia, mice were injected with 1mg of D,L-CBHcy. This reduced BHMT activity (87%) and elevated total plasma Hcy (tHcy, 2.7-fold) for 8 hours. Repeated intraperitoneal injections of D,L-CBHcy (6 doses) additionally reduced the liver …
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Synthesis of S-Ribosyl-L-homocysteine and Analogs Modified at the Homocysteine-C3 Position
… The LuxS enzyme converts <em>S</em>-ribosyl-L-homocysteine (SRH) into homocysteine (HCys) and 4(<em>S</em>),5-dihydroxypentane-2,3-dione (DPD), which is the precursor of autoinducer-2 (AI-2). Thus, inhibitors of LuxS could prevent QS by halting the conversion of SRH to AI-2 rendering the cell …
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The Role of Potassium in Betaine-Homocysteine Methyltransferase
Homocysteine (Hcy) is an intermediate of methionine metabolism and acts as a critical branch point between protein synthesis and numerous regulatory pathways in the cell. Elevated plasma total Hcy (tHcy) is associated with an increased risk for cardiovascular disease, although the mechanism by …
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Interrelationships Among Sulfur Amino Acids, Choline and Betaine in the Chicken: Effects on Betaine-Homocysteine Methyltransferase Activity, Homocysteine Utilization and Choline Bioavailability
… effects of dietary changes on hepatic betaine-homocysteine methyltransferase (BHMT) activity. In Assay 1, use of a methionine-deficient purified diet caused a 3-fold increase $(P<0.05)$ in BHMT activity, and addition of choline or betaine further increased $(P<0.05)$ activity. In Assay 2, use …
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Effects of Homocysteine on Cardiac Neural Crest Cell Formation
Elevated homocysteine (Hcys) causes a wide spectrum of congenital detects, many of which resemble neural crest (NC) cell ablation. However, the etiological mechanism is not known. The purpose of this study was to determine if Hcys altered the number and/or the proliferation of NC cells or their …
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Developmental and evolutionary analysis of betaine homocysteine methyltransferase genes
… amino acid because mammals cannot synthesize homocysteine. Betaine-homocysteine methyltransferase (BHMT) and BHMT-2 methylate homocysteine to form methionine using betaine and S-methylmethionine, respectively. Betaine is produced de novo from choline and is also found in the diet, whereas …
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C-Reactive Protein, Homocysteine, And Cognitive Performance In Healthy Adults
… blood levels of C-reactive protein (CRP) and homocysteine (Hcy) have received a great deal of attention as biomarkers for the development of cardiovascular disease. Their utility in predicting cognitive function has also been assessed, though the findings are equivocal. The current study …
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Investigations of Thioether Generation for S-D-Ribosyl-L-homocysteine Synthesis
… quorum sensing molecule <em>S</em>-D-ribosyl-L-homocysteine (SRH). Although previous preparations of SRH and its analogues have been reported in the literature, they employ assorted methods with varied results. Therefore, a reassessment of the methodology used for synthetic preparation of the …
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The effects of exercise on homocysteine levels in men and women
… Heart Disease, is elevated levels of serum homocysteine (Boushley et al., 1995; Malinow et al., 1994; Malinow et al., 1999; Nygard et al., 1995; Stampfer et al., 1992). Serum homocysteine levels above 10 umol/L are considered elevated. There are several unalterable factors, which result in …
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Total Plasma Homocysteine, Vitamins, Abdominal Aortic Aneurysm and Peripheral Vascular Disease
<b>Introduction</b><br/>Hyperhomocysteinemia (>15µmol/L) is a recognised independent risk factor in the genesis of vascular diseases. There are few data on the relationship between homocysteine and abdominal aortic aneurysm (AAA), peripheral vascular disease (PVD), and the effect of vitamin …
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Bioanalytical methods for studies of homocysteine and novel cardiovascular disease indicators
… to investigate the chemical reactivity of homocysteine (Hcy), an independent CVD risk factor and serological biomarker. Consequently, we proposed an alternate theory for in vivo Hcy clearance based on spontaneous pyridoxal tetrahydrothiazine (PT) formation from Hcy and pyridoxal. The …
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Direct detection of homocysteine and syntheses of lanthanide complexes as biosensors
At elevated levels, homocysteine (Hcy) is a risk factor for cardiovascular diseases and Alzheimer’s disease. It’s also implicated in a number of other diseases such as neural tube defects, pregnancy complications, and renal failures. The monitoring of Hcy levels in plasma is of current concern. To …
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The Relation between Daily Calcium Intake and Serum Homocysteine Concentration of Adults
"연구배경: 혈중 호모시스테인이 상승할 경우 각종 심혈관계 질환의 위험이 증가하게 된다. 따라서 이를 예방하기 위해 혈중 호모시스테인을 감소시킬 필요성이 대두되고 있고, Vitamin B12, folic acid 등이 효과적인 대안으로 제시되고 있고 최근에는 folic acid, Vitamin B12와 함께 칼슘을 강화시킨 물을 마셨을 때 혈중 호모시스테인 수치가 감소함을 밝힌 여러 연구들도 있다. 본 연구에서는 일일 칼슘섭취량과 혈중 호모시스테인과의 관계를 살펴보고자 하였다. 방법: 2006년 5월부터 2007년 4월까지 일개 …
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Betaine-Homocysteine Methyltransferase: Tissue Distribution, Nutrient Regulation, Genomic Organization, and Promoter Isolation
… to be 2160 muM and <10 muM for betaine and L-Homocysteine, respectively. These constants were same as the published human liver BHMT constants. Thus, we conclude that kidney and liver BHMT proteins are the product of one human BHMT gene.
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New Insights Into the Structure and Function of Betaine-Homocysteine S-Methyltransferase
… of patients have elevated levels of plasma total homocysteine (Hcy), which is now considered a risk factor for cardiovascular disease, stroke, and Alzheimer's disease. Endothelial damage may be caused by Hcy-induced vascular oxidative stress. Hcy is not a dietary amino acid, but is an important …
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Implication of homocysteine, resistin and vitamin D in development of type 2 diabetes
… resistance, among them vitamin D, resistin and homocysteine which can interrupt the insulin signalling pathway leading to insulin resistance. Elevated levels of homocysteine have been observed in patients with T2DM and metabolic syndrome, while resistin (a hormone) was suggested to play a role …
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CHANGES IN SERUM HOMOCYSTEINE LEVELS AFTER ROUX-EN-Y GASTRIC BYPASS SURGERY IN SEVERE OBESITY
Homocysteine is a sulfur-containing amino acid that is formed after the demethylation of methionine. High levels of plasma homocysteine have been proposed as a major and independent risk factor for cardiovascular disease. It is well known that obesity is also a modifiable and independent risk …
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