Global ETD Search
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Showing 1 to 6 of 6 for “"Homoallylic amines"”.
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Hydroamination of terminal allylic imines, allylic amines, and internal and terminal homoallylic amines: Regioselective and regiodivergent transformations
… The intermolecular hydroamination of alkenes and amines represents a novel approach towards these disconnections from readily accessible functional groups. This transformation can streamline the synthesis of complex molecules and often allows access to two regioisomers (Markovnikov and …
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A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
… through the intermediacy of α-halo enamines/enamides. The synthetic utility of the method is exemplified through the construction of quaternary cyclic propargylic and homoallylic amines, polycyclic lactams, as well as chiral dihydro 1,4-oxazines and thiazines. Given the generality of …
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Palladium assisted ring closures
… yield. The cyclization of the corresponding amines, cis and trans methyl-N,N-dimethyl-2-carhomethoxy-7-amino-hept-5-en-1-oate, proceeded more rapidly and stereospecifically generate stable fused bicyclic palladium complexes in excellent yield. NMR studies revealed the bicyclic complexes …
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The Development of Palladium and Cobalt-Catalyzed Methods for the Syntheses of alpha-Trifluoromethyl and Alkyl Amines
… of methodologies for the construction of chiral amines in organic synthesis. Amongst these chiral amines, a-trifluoromethyl and alkyl amines are an important subclass that have been sought after because of their relevance in drug discovery. With respect to a-trifluoromethyl amines, the role of …
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DEVELOPMENT OF METAL-CATALYZED REACTIONS OF ALLENES WITH IMINES AND THE INVESTIGATION OF BRΘNSTED ACID CATALYZED ENE REACTIONS
… acid catalyzed ene reactions provide access to homoallylic amines and alcohols. However, the scope of this type of catalysis is limited because of the need for inert conditions, the metal waste generated, and the metal’s stronger chelation to the product than the starting material. As an …
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New Strategies and Transformations for the alpha-Functionalization of Amines to Access Chiral Amines
… methodologies to prepare alpha-functionalized amines, especially chiral amines have been studied in this work. Specifically, we focused our work on introducing alpha-functionalization to amines through C–C forming processes. This thesis work is inspired by the vitamin B6 transamination process: …