Global ETD Search

Régulation du récepteur aux opioïdes de type delta par les protéines Homer1

Grisé, OlivierUniversité de Sherbrooke2025

… that its short and long isoforms, namely Homer1a and Homer1b, regulate the cell-surface expression of various GPCR. Furthermore, neuropathic and inflammatory models demonstrated pain modulation by Homer1. We thus hypothesized that Homer1 isoforms regulate DOP. Resuming preliminary work on …

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Cellular and Circuit Consequences of a Genetic Locus for Attention

Gershon, Zachary

… period of two short, activity-dependent isoforms Homer1a and Ania3 led to significant improvements in multiple measures of attentional performance in the adult. Subsequent single-cell RNA seq experiments revealed that prefrontal Homer1 down regulation in excitatory neurons is associated with …

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Molecular alterations of AMPA receptors and their effects on hippocampus dependent tasks

Marx, VerenaUniversität Heidelberg

… function using mice engineered to express Homer1a constitutively in the neocortex. The results of the studies presented in this thesis showed that hippocampal contributions to the expression of the emotional responses, emotional and motor learning as well as spatial working and reference …

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Non-uniform excitability of hippocampal neurons affords weak predictability of future immediate-early gene expression patterns

Demchuk, Aubrey M.2014

lethbridge