Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Homeostatic proliferation"”.
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… transpresent IL-15 to support the survival and homeostatic proliferation of memory CD8 T cells is unknown. Using a transgenic mouse model that limits IL-15 transpresentation to DCs, I have demonstrated that DCs transpresent IL-15 to CD8 T cells. DCs transpresent IL-15 to CD8 T cells during the …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… transpresent IL-15 to support the survival and homeostatic proliferation of memory CD8 T cells is unknown. Using a transgenic mouse model that limits IL-15 transpresentation to DCs, I have demonstrated that DCs transpresent IL-15 to CD8 T cells. DCs transpresent IL-15 to CD8 T cells during the …
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A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… IL-7R[alpha] signaling is also responsible for homeostatic proliferation of T cells in lymphopenic hosts, as well as maintenance of naïve and memory CD8+ T cells in the periphery. A number of regulators of IL-7R[alpha][alpha] have been identified, but the complex processes underlying fine …
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Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
… and is involved in the homeostasis and proliferation of lymphocytes. This thesis investigates the role of antagonism of IL-7Rα in the treatment of MS in humans and in vitro differences between genetically stratified subjects based on IL-7Rα genotype. It also explores the role for …
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Biodistribution and Modes of Action of Multipotent Adult Progenitor Cell therapy in Murine Models of Transplant Rejection
T cell homeostatic proliferation (HP) and Graft versus Host Disease (GvHD) are major barriers to the success of transplantation. Multipotent Adult Progenitor Cells (MAPC cells) have demonstrated promising safety and therapeutic profiles in experimental models and small clinical trials of …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… in vitro cytokine polarisation assays, in vivo homeostatic proliferation models and antigen-driven memory formation and rechallenge influenza A virus infection models. Across all systems tested, loss of Ihh or Gli1 in T cells had no effect on memory formation. Taken together, I have developed a …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… human myeloid dendritic cells (mDC) to cause the homeostatic proliferation of autologous CD4+ T cells that serve as targets for HIV infection. Rhesus macaques inoculated with simian immunodeficiency virus (SIV) or with the simian-human immunodeficiency virus (SHIV) by the vaginal, oral or rectal …
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Roles for the E3 Ligase Itch in Immune Response Modulation
… remains unclear, although an increase in homeostatic proliferation of the memory-like cells is considered unlikely. The findings of this thesis provide definitive support for several speculations regarding the function of Itch. In addition, they provide novel venues of study for the role …
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Multigenic Regulation of the Shutdown of Immune Responses
… surface marker expression, cytokine production, homeostatic proliferation, and ability to clear a secondary challenge of pathogen. In contrast, chronic LCMV infection of Bim-/-Faslpr/lpr mice resulted in similar numbers of antigen-specific CD8+ T cells compared to the Bim-/- parental genotype. …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… in normal or increased numbers consistent with homeostatic proliferation. Thymocytes showed evidence of developmental defects, including 50% decreased CD4+CD8+ double positive (DP) cells with lower CD5 expression and greatly decreased NKT cells. The percentage of CD4+ or CD8+ single positive …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… in normal or increased numbers consistent with homeostatic proliferation. Thymocytes showed evidence of developmental defects, including 50% decreased CD4+CD8+ double positive (DP) cells with lower CD5 expression and greatly decreased NKT cells. The percentage of CD4+ or CD8+ single positive …