Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Homeobox genes"”.
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Role of Msx homeobox genes in uterus during embryo implantation
… the uterus is a crucial event in mammalian embryogenesis. This complex event involves a series of interactions between the developing embryo and the receptive endometrium ultimately leading to successful establishment of pregnancy. The sequential events of implantation include apposition of the …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… contain a 60 amino acid DNA binding motif called homeobox that regulates a variety of developmental events. Recently, a novel cluster of homeobox genes has been discovered on the X chromosome of the mouse. Because of their selective expression in reproductive organs, they are named Reproductive …
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Homeobox gene and microRNA duplication in Chelicerata
… by the evolution of core development toolkit genes. The expansion of these toolkits via gene duplications is correlated with the evolution of multi-cellilarly and morphological complexity in metazoans. Small tandem duplications are a common source of additional genetic material in animals, …
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Hox3 duplication and divergence in the Lepidoptera
… cluster of the Lepidoptera, called the Special Homeobox genes. An annotation of this duplicated cluster across a wide number of Lepidoptera was performed in order to assess patterns of duplication and loss across the order. The sequences recovered revealed a large amount of variation associated …
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The role of the Fused toes locus containing Iroquois homeobox gene 3, 5, and 6 and Ftm, Fto, and Fts during ovary and testis development in mice
… of the Fused toes (Ft) locus, which includes six genes: homeobox genes: Irx3, Irx5 and Irx6 and three other genes: Fto, Fts, and Ftm, during male and female gonad development. Ft mutant mice are missing Ft locus genes whose function is unknown during male and female gonad development. These six …
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Unravelling the Origins and Evolution of the Animal Kingdom using Genomics
… The same core pipeline was used to extract homeobox gene HGs, a key family usedto understand origin and diversification in animals. Gene trees were inferred from the core datasetHGs to determine the evolution of a gene family iconic in the study of animal body plans. Conservedanimal genes …
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Genexpression während der Zahnentwicklung der Maus (Mus musculus)
… the development of the lower jaw. Molar morphogenesis in the maxillary starts from the mesenchyme, influenced by genes like Barx1, Dlx2 and Dlx2. At the same time the absence of genes like Msx1 and genes from the Alx-family is necessary for a normal development (McCollum and Sharpe, 2001). The …
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Molecular phylogenetics of the Metazoan clade Lophotrochozoa
… of the bryozoan Bugula turrita. Six Hox genes were recovered, including an ortholog of the posterior class gene Post2, which is a synapomorphy for the Lophotrochozoa. The identification of a Post2 ortholog provides evidence of a close relationship between the Bryozoa and other …
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Characterizing the Hypothalamic Functions of Irx3 and Irx5 in Energy Balance Regulation
… evidence has suggested that postnatal neurogenesis in ARC contributes to energy balance regulation and obesity, little is known about the genetic factors that are involved in this process. Using marker gene staining, lineage tracing and single-cell RNA sequencing analyses, I demonstrate that …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… in a highly coordinated manner during early neurogenesis. Specification of these cells at distinct positions along the dorsoventral (DV) axis of the developing spinal cord is controlled by a ventrally located signaling center, the medial floor plate (MFP). Currently, the origin and time frame of …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… The transcription factor encoded by the homeobox patterning gene <em>DLX4</em> is overexpressed in a wide range of malignancies. In this study, I demonstrated that DLX4 blocks the anti-proliferative effect of TGF-b by disabling key transcriptional control mechanisms of the TGF-b …