Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Homeobox Gene"”.
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Homeobox gene and microRNA duplication in Chelicerata
… morphological phenotypes that has probably been generated by the evolution of core development toolkit genes. The expansion of these toolkits via gene duplications is correlated with the evolution of multi-cellilarly and morphological complexity in metazoans. Small tandem duplications are a …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… contain a 60 amino acid DNA binding motif called homeobox that regulates a variety of developmental events. Recently, a novel cluster of homeobox genes has been discovered on the X chromosome of the mouse. Because of their selective expression in reproductive organs, they are named Reproductive …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… are poorly understood. <em>HOXA9</em>, a homeobox gene that is normally expressed in the developing female reproductive tract, is aberrantly expressed in EOCs and controls the morphologic features of these tumors. The differentiation pattern of a tumor is an important determinant of its …
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Functions of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling and Metastasis of Epithelial Ovarian Cancer
… treatment of advanced stage disease. The homeobox gene <em>DLX4 </em>encodes a transcription factor that is absent from most normal adult tissues. Previous studies from our laboratory have identified that DLX4 is highly expressed in advanced stage EOC and is strongly associated with …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… The transcription factor encoded by the homeobox patterning gene <em>DLX4</em> is overexpressed in a wide range of malignancies. In this study, I demonstrated that DLX4 blocks the anti-proliferative effect of TGF-b by disabling key transcriptional control mechanisms of the TGF-b …
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The role of the Fused toes locus containing Iroquois homeobox gene 3, 5, and 6 and Ftm, Fto, and Fts during ovary and testis development in mice
… of the Fused toes (Ft) locus, which includes six genes: homeobox genes: Irx3, Irx5 and Irx6 and three other genes: Fto, Fts, and Ftm, during male and female gonad development. Ft mutant mice are missing Ft locus genes whose function is unknown during male and female gonad development. These six …
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WHO: A Novel Wuschel-Like Homeodomain Transcription Factor in Arabidopsis
… a novel homeodomain transcription factor gene in Arabidopsis. It shares a high degree of identity with WUSCHEL (WUS), a transcription factor involved in specifying stem cell fate in shoot and floral meristems among several plant species. This novel homeobox gene, designated as …
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Gut Patterning In Development And Evolution: A Comparative Differential Transcriptomics Approach
… and cis-regulatory elements that compose the Gene Regulatory Network (GRN) essential for the development of the body plan. Modifications within the elements of the GRN determine the evolution of animal forms. In this study, the GRN for embryonic gut specification in two echinoderm species, the …
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MICROMORPHOLOGY AND GENE EXPRESSION IN MUSCLE AND SHELL DEVELOPMENT OF THE MOLLUSCA
… of this study deals with scaphopod shell morphogenesis and expression of the homeobox gene engrailed (en), in order to gain insights regarding the scaphopod-bivalve relationship. The results enable far reaching conclusions regarding the evolution and the phylogeny of the Mollusca. Solenogastres …
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Esx1 Dosage Impacts Reproductive Fitness: Effects On Viability and Fertility
<p>Numerous genes expressed in placenta or testis localize to the X-chromosome. Both tissues undergo specialized X-chromosome inactivation (imprinted paternal inactivation in placenta and MSCI in testicular germ cells). When the X-chromosome is duplicated or improperly inactivated, defects in …
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Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance
Polycomb group (PcG) proteins are epigenetic gene silencers that have been implicated in stem cell maintenance and cancer development. Genetic and biochemical studies indicate that Polycomb group proteins exist in at least two protein complexes, Polycomb repressive complex 2 (PRC2) and Polycomb …
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Unravelling the Origins and Evolution of the Animal Kingdom using Genomics
… including comparative genomics (e.g., gene loss/gain, non-coding regions, synteny, etc),gene family evolution, and their evolutionary relationships using genome-wide data. No study to date has compared all the wealth of genomic data available to understand theevolution of the Animal …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
… neural retina (CNR) lacks the capability to regenerate, a phenomenon retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the presumptive neural …
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Appendage development and early Distal-less regulation in arthropods: A study of the chelicerate Tetranychus urticae (Acarida)
… the myriad body plan morphologies expressed both genetically and phenotypically within the animal kingdom. Arthropods exhibit an astounding array of morphological diversity both within and between representative sub-phyla, thus providing an ideal phylum through which to address questions of body …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… in a highly coordinated manner during early neurogenesis. Specification of these cells at distinct positions along the dorsoventral (DV) axis of the developing spinal cord is controlled by a ventrally located signaling center, the medial floor plate (MFP). Currently, the origin and time frame of …
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The zebrafish maternal factor pollywog is required for yolk syncytial layer morphogenesis
… endoderm found in mice and is required for morphogenesis of the overlying blastoderm. The YSL undergoes dramatic reorganization during early development through processes that mirror the morphogenetic movements of the blastoderm. The YSL and YSL nuclei (YSN) undergo epiboly, and during convergence …
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Funktionelle Charakterisierung der Transkriptionsfaktoren Nkx2.2 und Arx in der Entwicklung der endokrinen Zellen im murinen Pankreas
… ein Transkriptionsfaktor aus der Klasse der NK-Homeobox-Gene, In Nkx2.2-Knockout-Mäusen sind die Beta- und Alpha-Zell Populationen stark reduziert, wohingegen ein Ghrelin-exprimierender Zelltyp dominiert. Interessanterweise sind in Nkx2.2-defizienten Pankreata fünf-fach erhöhte …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… (myeloid ecotropic viral integration site 1) gene belongs to the three-amino-acid loop extension subclass of homeobox gene families, and it is a highly conserved transcription factor in all eukaryotes. Up to date, little is known about the role of Meis1 in regulating vascular remodeling under …
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Der Transkriptionsfaktor Hex markiert eine Subpopulation von Endothelzellen bei der Embryonalentwicklung und der Tumorangiogenese
Das Homeobox-Gen Hex reguliert bei Vertebraten eine Vielzahl von Entwicklungsprozessen und steuert dabei die Zellproliferation und Differenzierung. Ziel dieser Arbeit ist es, das Hex-Expressionsmuster sowohl in der Frühphase als auch in späteren Entwicklungsstadien bei Hühnerembryonen zu …