Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Holliday"”.
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Characterisation of potential Holliday junction resolvases in Trypanosoma brucei
… a promising opportunity to treat the infection. Holliday junctions are an essential part of homologous recombination, which is used for DNA repair and for the crossover of DNA. Identifying T. brucei proteins which act as Holliday junction resolvases are potential candidate targets for inhibiting …
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The role of Bacteroides Host Factor A in CTnDOT integration and Holliday junction resolution
… The first set of strand exchanges generates a Holliday junction (HJ) intermediate that isomerizes through an overlap region and which is resolved by a second set of strand exchanges. Most tyrosine recombinases require identical DNA sequences in the overlap region where the strand exchanges …
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A Historic Acquittal Re Examined: Would the Earps and Doc Holliday Escape Indictment Under The Modern Grand Jury System
… along with Wyatt's close friend John Henry "Doc" Holliday, stood accused of murder in the deaths of William "Billy" Clanton, Frank McLaury, and Tom McLaury. Justice of the Peace Wells Spicer, applying the laws of the Territory of Arizona, determined after an evidentiary proceeding that there was …
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Molecular mechanics of DNA bricks: in situ structure, mechanical properties and ionic conductivity
… similar to the structure of individual Holliday junctions in solution, which contrasts with the left-handed structure of Holliday junctions in DNA origami. Subject to external electric field, a DNA brick plate is more leaky to ions than an equivalent DNA origami plate because of its …
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Analysis of Structure-Function Relationships in *Lambda and HK022 Site -Specific Recombination
… Int mutants were characterized that resolved Holliday junctions with biases different from the wild-type Int. The T168N and E153K substitutions may directly affect cooperative interactions between Int proteins bound to the Holliday junction intermediate. The V175E substitution appears to …
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Solving the crystallographic structure of the Cl2J construct and occupancy titration trials to quantitatively determine isomer ratio
… the study of halogen bonds is the 4-stranded DNA Holliday junction. Incorporating engineered halogen bonds into the structure results in halogen bonds competing energetically against hydrogen bonds for stabilization of the junction. The structure that was refined in order to analyze chlorinated …
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5-hydroxymethylcytosine and endonuclease G as regulators of homologous recombination
… 5hmC forms a unique hydrogen bond to stabilize Holliday junctions, the four-stranded DNA intermediate in HR. 5hmC also induces a global structure change to the junction, increasing protein access to the junction crossover and providing potential for either direct or indirect readout of 5hmC. …
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Characterization of the Integrase of the Bacteroides Mobilizable Transposon NBU1
… system. I used nicked attBT1-1 substrates and a Holliday junction trapping peptide to show that NBU1 integration proceeds via formation of a Holiday junction intermediate that is formed by exchange of bottom strands. Some mismatches next to the first strand exchange site (in reactions with C(-3)G …
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Single molecule studies of helicase mechanisms
… DNA structures such as G-quadruplexes and Holliday junctions. Ensemble biochemical research has shown that BLM probably has roles in the maintenance of genome integrity by disrupting non-canonical DNA structures and migrating Holliday junctions to allow for continuation of replication forks …
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Formal Models of Fallible Knowledge
In this thesis I review and analyze Holliday’s \citeyearpar{KWF} work on the relation between fallibilism and closure. The main concern in Holliday’s work is to show that most major fallibilistic theories of knowledge inherently suffer from at least one problem among a set of problems and that …
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The Role of Esc2 and DNA in Smc5/6-mediated Sgs1-Top3-Rmi1 Sumoylation
… to the formation of DNA intermediates such as Holliday junctions (HJ), which are processed by one of two mechanisms: resolution or dissolution. In double Holliday junction dissolution, Sgs1-Top3-Rmi1 (STR) complex in yeast creates non-crossover products, and this process is regulated by …
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Development of VHH- and antibody- based imaging and diagnostic tools
… fluorophores localized in close proximity, Holliday junctions were used to label proteins site-specifically with fluorophores. Holliday junctions enable the introduction of multiple fluorophores with reasonably precise spacing to improve fluorescence yield for both single domain and …
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A study of DNA-DNA interactions during bacteriophage lambda integrative recombination
… however, required for branch migration of the Holliday-structure intermediate formed by the first strand exchange. The results also indicate that the first strand exchange reaction is reversible during the integrative recombination.
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Teaching and learning German language and culture in higher education in Britain:problems, challenges and didactical implications. A case study
… and learning German. Following Lamb (2004) and Holliday (1994), the present study acts on the assumption that each micro-context does not exist in vacuo but is always embedded in a wider socio-political and education environment, namely the macro-context, which largely determines how and what is …
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Modeling and Simulating Biomolecular Machineries at Atomic Scale and Beyond
… central pore; (3) a four-way DNA junction (Holliday junction), a central intermediate in homologous recombination, for which we have constructed a minimum geometric model and deduced a schematic framework of its conformer transition. The studies have been conducted mainly by modeling the …
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Determining High School Geometry Students' Geometric Understanding Using van Hiele Levels: Is There a Difference Between Standards-based Curriculum Students and NonStandards-based Curriculum Students?
… Research done by Rey, Reys, Lappan and Holliday (2003) showed that Standards-based curricula improve students' mathematical understanding and performance on standardized math exams. Using van Hiele levels, this study examines 20 ninth-grade students' levels of geometric understanding at …
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Self-directed curriculum renewal: A process analysis in one university French program
… to curriculum design are the Ecology Model (Holliday and Cook, 1983) and the Appropriate Technology model (Markee, 1986), are related to a more traditional Munby-style needs analysis (Munby, 1978) and complement it with a learning environment analysis which they call a Means Analysis. In this …
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The Poetics of Appeal
This study advances a theoretical model of appeal, the framework readers’ advisory (RA) librarians use to make book suggestions. Taking an interdisciplinary approach, it combines elements of media studies, literary theory, and library science to posit new elements of appeal and new models for …
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Graphs of Classroom Networks
<p>In this work, we use the Havel-Hakimi algorithm to visualize data collected from students to investigate classroom networks. The Havel-Hakimi algorithm uses a recursive method to create a simple graph from a graphical degree sequence. In this case, the degree sequence is a representation of the …
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The Performance of Aerofoil Cascades Using Circulation Control
The performance of a cascade of two-dimensional, bluff aerofoils employing circulation control by a tangential blowing jet is investigated. Expressions for the lift and drag of such a cascade are derived to eliminate the direct effect of the blowing jet on the measured performance. The cascade …
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