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Showing 1 to 20 of 42 for “"Hodgkin Lymphoma"”.
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… cancers, including various leukemias and lymphomas, are among the top 10 cancers diagnosed in people. The leukemia and lymphoma society estimates that there are nearly 1.7 million people in the United States living with or in remission from hematological cancers. The frontline therapeutics …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
The commonest childhood Non-Hodgkin Lymphomas (NHLs) form three major categories: the aggressive mature B-cell NHLs including Burkitt lymphoma (BL), Anaplastic Large Cell Lymphomas (ALCL), and lymphoblastic lymphomas. Most childhood NHL is high-grade and generally responds well to high-intensity …
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HIV-associated Hodgkin lymphoma at Groote Schuur Hospital, Western Cape, South Africa
… associated with an increased risk of developing Hodgkin lymphoma (HL). South Africa (SA) has the highest HIV prevalence rate in the world. There is currently no 5-year overall survival (OS) outcome based data for HIV-associated HL from SA. Methods: A bone marrow database was compiled of all bone …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
Paediatric mature B-cell non-Hodgkin lymphoma (B-NHL) is a highly aggressive disease with one of the fastest growth rates of any human malignancy. The subtypes are Burkitt and Burkitt-like lymphoma/leukaemia, diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma; with Burkitt …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
Hodgkin lymphoma (HL) cancer cells account for less than 5% of the tumour microenvironment, yet drug screening and treatment strategies typically focus on targeting malignant cells. Tumour-associated macrophages (TAMs) are associated with poor prognosis and resistance to therapy; however, there …
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The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances
Hodgkin lymphoma (HL) is a malignant lymphoma that is diagnosed mostly in young adults, and is the second most common malignancy to affect this age group. This disease is subdivided into two entities with different aetiologies: classical HL (cHL) (~95% of cases) and nodular lymphocyte-predominant …
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Radiogenic Second Cancer Risk Differences In Female Hodgkin Lymphoma Patients Treated With Proton Versus Photon Radiotherapies
<p>Hodgkin Lymphoma (HL) is the most common cancer diagnosis of young adults in the United States. Advances in curative treatments for HL, including the use of photon radiation therapy (RT) techniques, have increased 10 year survival rates to approximately 90% among young patients. These RT …
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Psychosocial Adjustment to Cancer in Younger Adults with Hodgkin Lymphoma or Testicular Cancer: Transitions to Survivorship
… developmental milestones. Testicular cancer and Hodgkin lymphoma typically affect young adults, however relatively few studies have explored the psychosocial impact of these cancers. This thesis aimed to explore the process of psychosocial adjustment to these cancers in young adulthood in order …
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The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was …
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Molecular Profile of Women With and Without Secondary Breast Cancer After the Treatment of Pediatric Hodgkin Lymphoma
… and mortality. Women survivors of pediatric Hodgkin lymphoma (HL) have an increased risk of morbidity and mortality associated with secondary effects of therapy, with a 35-75 fold excess risk of developing breast cancer over the general population. The mechanism for secondary breast cancer …
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Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing
… lapsesta on todettu nuorellä iällä klassinen Hodgkinin lymfooma (cHL). Perinnöllinen alttius cHL:lle tunnetaan huonosti, eikä taudille mahdollisesti altistavia geenimuutoksia ole aiemmin raportoitui kuin yksi kappale. Geenimuutosten selvittämiseksi eksomisekvensoimme kolmen sairastuneen lapsen …
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Clinical-pathological characterisation of children with B-cell non-Hodgkin lymphoma over a ten year period at a tertiary centre in Cape Town
Background: We characterized B-cell non-Hodgkin lymphoma (NHL) cases over ten years at a tertiary children's hospital to contribute to the body of knowledge on pediatric lymphoma in developing countries with a high human immunodeficiency virus (HIV) burden. Methods: A retrospective cohort study …
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Evaluation of prognostic risk factors at diagnosis and treatment outcomes in adult patients with early-stage hodgkin lymphoma in Cape Town, South Africa
… a recognized standard for prognostic staging in Hodgkin Lymphoma (HL). We aimed to determine if the NCCN staging system and its individual risk factors correlated with patient treatment outcomes in early-stage adult classical HL (cHL) patients. This retrospective study included 70 patients …
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CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients
… poorer outcomes in HIV-negative patients with Hodgkin lymphoma (HL), but whether this is true in HIV positive patients with HL is not known. In this study, we investigated the number of CD68-positive TAMs and expression of programmed cell death-ligand 1 (PD-L1) in lymph node specimens from HL …
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Scanned Ion Beam Therapy For Thoracic Tumors
<p>Although frequently cured of Hodgkin lymphoma, adolescents and young adults can develop radiation induced second cancers. These patients could potentially benefit from scanned ion radiotherapy yet likely would require motion mitigation strategies. In theory, four-dimensional (4D) optimization of …
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Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants
… malignancies were identified (2.97%): non-Hodgkin lymphoma in 9/706 individuals (1.27%), chronic myeloid leukemia and multiple myeloma each in 2/706 individuals (0.28%), respectively, and acute myeloid leukemia, unspecified leukemia, and Hodgkin lymphoma each in 1/706 individuals (0.14%). …
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Cancer incidence by Ethnic Group in England, 2001-2007
… higher rates of head & neck, liver, gallbladder, Hodgkin lymphoma and thyroid cancer and Blacks having higher rates of stomach, liver, gallbladder, prostate, endometrium, non-Hodgkin lymphoma, myeloma, thyroid and childhood cancers. There also was strong evidence of differences in risk between …
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Review of Diffuse large B cell lymphoma, pharmacological aspects of treatment and comparison of outcome between Pre-,Post Rituximab era
Diffuse large B Cell lymphoma (DLBCL) is a type aggressive non-Hodgkin Lymphoma (NHL). About 30% of patients who diagnosed NHL is DLBCL in both male and female. It is divided into 3 major types which distinct by immunological characteristics. It shall shows variable spectrum of prognosis and …
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