Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Hodgkin Huxley"”.
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A computational framework for similarity estimation and stimulus reconstruction of Hodgkin-Huxley neural responses
… of frequencies, a behaviour modelled by the Hodgkin-Huxley equations. Inthe presence of chaotic oscillations, similarity between neural responses depends on their temporal nature as firing times and amplitudes together reflect the true dynamics of theneuron. This thesis presents a method to …
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Qualitative Models of Neural Activity and the Carleman Embedding Technique.
… behaves qualitatively like the four variable Hodgkin-Huxley space clamped system and is more mathematically tractable than the Hodgkin Huxley model, thus allowing the action potential and other properties of the Hodgkin Huxley system to be more readily be visualized. In this thesis, it is …
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Nonlinear observer design and synchronization analysis for classical models of neural oscillators
… classical models of neural oscillators, the Hodgkin- Huxley model, the Fitzhugh-Nagumo model, the Morris-Lecar model, and the Hindmarsh-Rose model. Analysis techniques for nonlinear systems were used to develop a set of observers and perform synchronization analysis on the aforementioned …
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Modelling the synaptic plasticity underlying habituation, sensitization and classical conditioning of the Aplysia Californica Gill Siphon withdrawal reflex
… of the well known neuron models, including the Hodgkin Huxley equations and the Leaky Integrate-and-Fire model. Also included is a brief description of some neural coding schemes. The next chapter explains the basic functioning of synapses and introduces some common forms of synaptic plasticity. …
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A study of synchronization of nonlinear oscillators: Application to epileptic seizures
… In the computational part, a network of a Hodgkin-Huxley type neocortical neural model is constructed. Phase reduction, which is a dimension reduction technique for a stable limit cycle, is applied to the system. The results propose a possible mechanism for the initiation of the …
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Evolution of Voltage-gated Ion Channels
… and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several other structural and gating features that come together to form a functional hetero- or homotetramer. A comprehensive phylogenetic study of all available …
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A Novel Dual Modeling Method for Characterizing Human Nerve Fiber Activation
… research concentrated on the utilization of the Hodgkin-Huxley electrical circuit representation of the nerve fiber membrane. Further development of the project identified the need for a linear circuit model that more closely resembled the McNeal linearization model augmented by the work of …
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The control of frequency of a conditional oscillator simultaneously subjected to multiple oscillatory inputs
… the model and are shown to extend to a detailed Hodgkin-Huxley type compartmental model of the gastric mill network. Comparisons to experiments are also presented.
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The role of short term synamptic plasticity in temporal coding of neuronal networks
… to represent a single neuron is based on the Hodgkin-Huxley model for the spiking neurons and we use techniques from geometric singular perturbation theory to show that any n-cluster solution must satisfy a set of consistency conditions that can be geometrically derived. The results of both …
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Respiratory function: A systems approach
… as a neuronal network. We develop and validate a Hodgkin-Huxley type neuronal model that can mimic, with biophysical realism, the response of isolated neurons in the ventral Nucleus Tractus Solitarius and Nucleus Ambiguus of experimental animals. Characteristic nonlinearities of neuronal behavior, …
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A study of phase resetting, mutual entrainment, and modified ventricular parasystole using a model of coupled heart cells
… physiologically realistic cell models of the Hodgkin-Huxley type. Furthermore, this caricature of the heart includes models representing cells from each of the major components of the heart's electrical conduction system, the SA node, AV node, Purkinje fibre network, and ventricular …
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Development of computational and experimental tools to study mechanotransduction in C.elegans and primates
… a micro spherical indenter. Finally, we use the Hodgkin-Huxley model to predict the membrane potential of the PLM mechanoreceptor in C.elegans and compare our results with experimental data in literature.
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Patterns of synchrony in complex networks of adaptively coupled oscillators
… Beispiel untersuchen wir ein Netzwerk von Hodgkin-Huxley-Neuronen mit "spike timing-dependent" Plastizität. Hier führt die Clusterung zur Aufspaltung einer neuronalen Population in einige wenige Gruppen, die mit unterschiedlichen Frequenzen synchronisiert sind. Wir führen ein …
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ULTRASTRUCTURAL NEURONAL MODELING OF CALCIUM DYNAMICS UNDER TRANSCRANIAL MAGNETIC STIMULATION
… a case study involving virtual reality with the Hodgkin-Huxley electrical model for voltage propagation. Additionally, I incorporate synaptic communication which is driven by TMS protocols or simulated by voltage clamps, and both provide a mechanism by which intracellular calcium transients …
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Identification of Dendritic Processing in Spiking Neural Circuits
… include conductance-based models such as Hodgkin-Huxley, Morris-Lecar, Fitzhugh-Nagumo, as well as simpler models of the integrate-and-fire and threshold-and-fire type. The aggregate time-varying current driving the spike generator is taken to be produced by a dendritic stimulus processor, …
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ESTIMATING PARAMETERS OF A MULTI-CLASS IZHIKEVICH NEURON MODEL TO INVESTIGATE THE MECHANISMS OF DEEP BRAIN STIMULATION
The aim of the research is to provide a computationally efficient neural network model for the study of deep brain stimulation efficacy in the treatment of Parkinson's disease. An Izhikevich neuron model was used to accomplish this task and four classes of neurons were modeled. The parameters of …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
Using the nucleated patch configuration that allowed me to investigate somatic ion channels under ideal voltage-clamp conditions, I started to examine the functional properties of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic …
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Preparation for Nerve Membrane Potential Readings of a Leech, Laboratory Setup and Dissection Process
A well documented laboratory setup, leech preparation process, and bio-potential data recording process are needed. Repeatability and quality data recordings are essential and thus dictate the requirements of the laboratory setup and processes listed above. Advances in technology have both helped …
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Action Potential Simulation of the Hirudo Medicinalis's Retzius Cell in MATLAB
<p>Modification of Hodgkin and Huxley’s experimentally derived set of nonlinear differential equations was implemented to accurately simulate the action potential of the <em>Hirudo Medicinalis’s</em> Retzius cell in <em>MATLAB</em> under analogous conditions to those found in the Retzius cell …
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Analysis of The Distributed Representation of Operant Memory In Aplysia
<p>Operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior, engages a high-dimensional neuronal population space spanning multiple brain regions. A complete characterization of an operant memory remains elusive. Some sites of plasticity …