Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HnrnpA1"”.
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA-binding proteins (RBPs) that are involved in many steps in gene regulation. The hnRNP family consist of 20 members which are expressed in humans (A1 to U). The first member identified being hnRNP A1; this is a …
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Role of hnRNP A1 in the Regulation of HDM2 Gene Expression
… repair 1. Our previous studies have shown that hnRNPA1 had reduced protein level and increased cytoplasmic accumulation in senescent human diploid fibroblasts 2,10. Our preliminary data showed that <em>HDM2</em> mRNA associates with hnRNPA1 in IMR-90 cells. We have also observed that alterations …
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Investigation of RNA-Binding Protein Expression Changes in the Hippocampus Following Doxorubicin and Cyclophosphamide Treatment
… of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) (21% decrease, p=0.0298), compromised astrocytic network integrity evidenced by reduced GFAP-positive area in cornu ammonis 3 (CA3) (24%, pB=0.026) and dentate gyrus (DG) (19%, pB=0.027) regions, and elevated cellular senescence marker …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… promoter regions of splicing factors PTBP1 and HNRNPA1, demonstrating that MYCN regulates splicing by directly regulating expression of key splicing factors. Furthermore, high expression of PTBP1 and HNRNPA1 was significantly associated with poor overall survival of stage 4 NBL patients …
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A Stress-Induced TRNA Depletion Response Mediates Codon-Based Translational Repression and Growth Suppression
… crosslinking immunoprecipitation (HITS-CLIP) of hnRNPA1 and SSB confirmed the mass spectrometry results and identified endogenous reciprocal interactions between the protein and tRF. Binding of this tRF to hnRNPA1 inhibits destabilization of endogenous targets of this RNA binding protein, leading …
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Tumor Suppression by a TRNA Synthetase
… in trans with RNA binding proteins, including HNRNPA1, to inhibit HNRNPA1-mediated transcript destabilization. These findings uncover and characterize a second adaptive, codon-based regulatory response that can contribute to cellular stress responses in physiology and disease.</p>
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… lead to decreased cytoplasmic accumulation of hnRNPA1 during osmotic shock and HRV infection, to a decrease in HRV-infected cells and to decreased caspase activation in osmotically stressed and HRV-infected cells. Thus, HK2 may regulate hnRNP A1 cytoplasmic localization following HRV infection.
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… containing stress granule proteins (HNRNPA2B1, HNRNPA1, MATR3, TIA1). Previous studies identified that a non-pathogenic variant of the non-classical MSP protein, TIA1 N357S , can act as a phenotype modifier with SQSTM1P392L leading to distal muscle weakness rather than proximal muscle weakness …
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Multiscale coarse-grained models for biological phase separation: Development and applications
… diagrams of an extensive set of proteins (*i.e.* hnRNPA1, FUS, *Laf* 1, DDX4) and their corresponding mutations. Lastly, we also investigated the role of Mg<sup>2+</sup>ions in regulating LLPS of intranuclear proteins. Atomistic-resolution simulations proved that minimal quantities of …
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Theoretical and Computational Studies on the Dynamics and Regulation of Cell Phenotypic Transitions
… We identified two RNA binding proteins, hnRNPA1 and KSRP, which repress each other through microRNAs miR-375 and miR-135a. The motif can generate switch behavior and serve as a noise filter in the stem cell differentiation process. Manipulating the motif could enhance the differentiation …
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Phase transitions in soft matter: From colloidal suspensions to biomolecular condensate regulation
… aggregation of proteins, namely FUS, TDP-43 hnRNPA1 and α1-antitrypsin. Finally, we aim to develop a computational framework to propose strategies to decelerate those structural transitions, which are commonly associated to the onset of neurodegenerative diseases, such as amyotrophic lateral …