Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hmlh1"”.
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Mutational analysis of the DNA mismatch repair genes, hMLH1 and hMSH2, in South African colorectal cancer patients
… tumours to be fully screened for mutations in hMLH1 and hMSH2 using exon-by-exon PCR single strand conformation polymorphism (SSCP) analysis. Sixteen pathogenic mutations were found in 14 tumours, 10/22 (45%) from black patients and 4/10 (40%) from caucasian patients. Five tumours presented …
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Identification of proteins interacting with the human mismatch repair protein MLH1
… of the human DNA mismatch repair (MMR) gene, hMLH1, is seen in a number of tumour cell lines resistant to a variety of cytotoxic drugs. The aim of this study was to identify other proteins that interact with hMLH1 to attempt to further elucidate its role in MMR and the engagement of downstream …
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Prevalence of gynaecological disease in women with an HMLH1 mutation in the Northern Cape province: Survey of a population with Lynch Syndrome in South Africa
… 25 premenopausal. 35 of these women had a known hMLH1 gene mutation. The eight remaining women had either normal genotyping (n=7) or were awaiting molecular test results (n=1). Only twenty-one of these participants agreed to endometrial sampling, in addition to pelvic ultrasound and …
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Elucidation of the occurrence of extracolonic cancers in Lynch syndrome
… the effect of a variant within the DNA MMR gene hMLH1 in a cohort of individuals predisposed to Lynch syndrome in order to examine a potential epistatic effect in the gene. In order to obtain a genetic signature of Lynch associated tumours, germline DNA and corresponding tumour DNA was isolated …
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Analysis of prognostic and drug resistance markers in lung cancer
… between 3p LOH (D3S1289, D3S1300, D3S1304) or hMLH1 promoter methylation and level of MLH1 expression. In addition this study attempted to correlate the presence of any molecular changes found in the serum DNA taken preoperatively from patients with those of their primary tumour samples. For …
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Effectiveness of Moviprep® as colonic preparation - cleansing right colon for Lynch Syndrome (LS) screening: a prospective study
… individuals who have a C1528T mutation in the hMLH1 gene that puts them at very high risk for the development of colon cancer (Lynch syndrome). A clean colon is essential as it allows a thorough evaluation and surveillance for small polyps or mucosal lesions mostly encountered in the ascending …