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Showing 1 to 6 of 6 for “"Histone ubiquitination"”.
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… levels of genes through both DNA methylation and histone post translational modifications (PTM). DNA methylation occurs when a methyl group is attached to the DNA strands generally at a cystine residue followed by a guanine. This phenomenon is generally associated with gene silencing, as genes …
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Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks
… modification (PTMs) including phosphorylation, ubiquitination, SUMOylation, methylation, acetylation, poly(ADP-ribosyl)ation, and Neddylation. In this study, I examined the role of phosphorylation and ubiquitination in regulating the DDR signaling at the DNA damage sites.</p> <p>DNA …
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
<p>Aberrant levels of histone ubiquitination are involved in various human diseases including neurodegenerative disorders and cancers. Particularly, Histone H2B monoubiquitination (H2Bub1) is highly associated with gene regulation in both normal cells and diseases. Many deubiquitinases (mainly …
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HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
Covalent modifications of histones play a critical role in many important biological processes such as transcription, DNA repair and recombination. Among the major modifications known so far, histone H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone H2B at lysine123 …
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Discovery of Novel Ubiquitin- and Methylation-Dependent Interactions Using Protein Domain Microarrays
… domain microarrays identifying novel readers for histone H2Aub1 and H2Bub1, and H3TM K4me3. Ubiquitinations of histone H2A at K119 (H2Aub1) and histone H2B at K120 (H2Bub1) function in distinct transcription regulation and DNA damage repair pathways, likely mediated by specific "reader" proteins. …
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Regulation of Set1-Mediated Methylation of Dam1
… in which DNA is wrapped around an octamer of histones forming the nucleosome. Histones are modified by a range of posttranslational modifications including methylation, phosphorylation, and ubiquitination, which are integral to a range of DNA-templated processes including transcriptional …