Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Histone lysine demethylase"”.
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
Small cell lung cancer (SCLC) arises from neuroendocrine cells within the lung. Along with deletion or loss-of-function RB1 and TP53 mutations, which occur in almost all cases, subsets of SCLC are driven by specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… of maternal imprints in the oocyte. KDM1B is a histone lysine demethylase whose activity is directed to H3K4me1 and H3K4me2, particularly within the gene body of actively transcribed genes. By generating CRISPR-Cas9-mediated knockout TSCs ablated for Kdm1b, I show that Esrrb is consistently …
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… program of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… program of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… program of mitotic entry through regulating histone lysine demethylase KDM4B, which is required for the epigenetic regulation of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… local chromatin environments by disrupting DNA-histone contacts. The Drosophila SWI/SNF counterpart, the Brahma complex, has been shown to have an essential role in regulating the proper expression of many developmentally important genes, including those required for eye and wing tissue …
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Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma
… state and identity of the cell. We showed that histone lysine demethylase subfamily 4 (KDM4) protein expression was higher in MYCN-amplified (MNA) NB cell lines and patient-derived xenografts (PDXs) compared with non-MNA counterparts. Additionally, genetic depletion of KDM4 correlated with …