Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Histone demethylase"”.
-
Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… of gene transcription. Among the most dynamic histone modifications are the acetylation and methylation at histone 3 lysine 9, but the precise roles of their modifiers in conserved transcriptional programs remain unknown. Using the poly I:C-induced transcriptional response in MEFs as our model, …
-
Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
… germline stem cells (GSCs). Mutations in Lsd1, a histone demethylase exhibit GSC-like tumor formation. Clonal analysis, cell-type specific knock down and rescue experiments demonstrate that Lsd1 functions within the escort cells that reside immediately adjacent to cap cells (niche). Loss of Lsd1 …
-
ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
… interact with LSD1 in other systems. LSD1 is a demethylase involved in transcriptional regulation, mainly acting on dimethylated lysine 4 of Histone H3 (H3K4me2). We showed that LSD1 inhibition sensitizes an APL cell line to physiological RA concentration. Here we characterize for the first time …
-
JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… modifications to the N-terminal tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which …
-
JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… modifications to the N-terminal tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which …
-
ALTERNATIVE SPLICING AND PHOSPHORYLATION PROVIDE A MECHANISTIC BASIS FOR FUNCTIONAL SPECIALIZATION OF LSD1/KDM1 HISTONE DEMETHYLASE IN THE CENTRAL NERVOUS SYSTEM
… of four mammal-specific variants of the histone demethylase LSD1 / KDM1 arising from combinatorial retention of two alternatively spliced exons, resulting in either ubiquitous isoforms or neuro-restricted ones, which are dynamically regulated during cortical development. The …
-
Analyzing The Interactions Of Kdm5/lid And Sin3 In Drosophila Melanogaster
<p>SIN3, the scaffold protein of a histone modifying complex is conserved from yeast to mammals. Drosophila SIN3 associates with both a histone deactylase RPD3 and a histone demethylase dKDM5/LID. Immunopurification of dKDM5/LID verifies a previously observed interaction with SIN3 and RPD3. …
-
Y Chromosome Gene Kdm5D Epigenetically Drives Sex Differences In Colorectal Cancer
… analyses identified Y-chromosome gene histone demethylase <em>KDM5D</em> as a transcriptionally up-regulated gene driven by KRAS*-mediated activation of the STAT4 transcription factor in cancer cells. KDM5D-dependent chromatin mark and transcriptome changes showed repression of …
-
Identification and Characterisation of the Barley Row-Type Gene <i>VRS3 </i>
… <i>VRS3</i> to be a highly conserved JmjC histone demethylase, with two natural alleles within European cultivated barley. <i>VRS3</i> was further characterised as a potential means of improving grain uniformity within cultivated six-rowed barley, through phenotypic assessment of grain size …
-
Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… Additionally, we found that lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates delta-catenin isoform 3 expression by modulating Epithelial Splicing Regulatory Protein (ESRP1), a delta-catenin splicing factor and epithelial marker. Taken together, this work reveals novel host …
-
Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
… clones, a disadvantage is observed for the histone modifier HDAC6, while at the other end of the spectrum, loss of the cohesin member STAG2 strongly advantages affected stem cells. Subsequent clonal expansion beyond the boundary of a single crypt is recognised by clones occupying multi-crypt …
-
A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… promising therapeutic strategy. Among these, the histone demethylase LSD1/KDM1A has been extensively studied, yet clinical responses to LSD1 inhibition remain variable. Work from our group demonstrated that pharmacological prolongation of the G1 phase of the cell cycle through sub-optimal doses of …
-
Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… deposit and remove chemical moieties from histone tails to aid in governing gene expression, and these proteins have become a new therapeutic target in cancer. Traditional chemotherapeutics aim to damage DNA, dysregulate cell division, or block hormonal growth signals, but epigenetic …
-
Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… pose high risks. DMG are characterized by histone mutations typically occurring in histone 3.1 and 3.3 alleles, with about more than 80% of patients containing the H3K27 mutation. Recent publications, highlight epigenetic modulators as promising cancer-specific targets emphasizing their …
-
Role of Chromatin Structure and JmjC Histone Demethylases in the Response to Hypoxia
… these changes remains largely unknown. Global histone methylation changes occur in response to hypoxia, however, temporal dynamics of histone methylation changes and how they correlate with hypoxia induced gene transcription changes is ill defined. The Jumonji C (Jmjc) histone demethylases are …
-
Modulating macrophage phenotype for obesity therapy
… based on a glucocorticoid receptor agonist and histone demethylase inhibitor. This combination works to both lower inflammatory gene expression and suppress expression of genes supporting macrophage metabolic dysfunction. I expect that this work could lead to the development of a dextran-drug …
-
Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
… that a mutation in a replication-dependent histone H3 gene his-9 transforms the MI neuron into an e3D-like cell. This mutant allele of his-9 causes an altered-function activity that is predicted to impair the interaction of the mutant HIS-9 protein with another histone H3 molecule and …
-
Studies of the MYM-type zinc finger protein ZMYM3
… mutation in this cluster, including: HDAC2, a histone deacetylase, LSD1, a histone demethylase, CoREST, a co-repressor of transcription, TFII-I, a transcription factor, and ZMYM3, an MYM-type zinc finger protein of unknown function. By making several truncation mutants of ZMYM3, I show that a …
-
Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer
<p>Histone modifications play important roles in regulating gene expression in various cellular processes by altering the underlying chromatin structure and thus influencing related pathological conditions. Histone methylation is one such modification that was thought to be static and enzymatically …
Page 1 of 2