Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Histone deacetylase 6 (HDAC6)"”.
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
… cancer cells. Finally, investigation of a novel histone deacetylase 6 (HDAC6)-selective inhibitor suggested that the cytoprotective role of the cytoplasmic histone deacetylase 6 (HDAC6) in response to proteasome inhibition may have been previously overestimated.</p>
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… treatment with a blood-brain barrier permeable histone deacetylase 6 (HDAC6) inhibitor successfully reverses long-term CICD following a therapeutic doxorubicin dosing schedule in female mice, as assessed by the puzzle box test and novel object/place recognition test. Long-term CICD was …
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Selective histone deacetlyase inhibition decreases disease in lupus-prone mice
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that acetylates several proteins that are involved in the immune response. HDAC6 inhibition has been shown in various models to decrease inflammation by altering various proteins involved in the dysregulation of B and T cell responses. In our …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… understood. Recently, it has been proposed that histone deacetylase 6 (HDAC6) binds to SIRPα, and that this binding interaction suppresses the STAT1 mediated pro-apoptotic pathway, thus protecting β-cells against death by apoptosis. It is not known how this interaction is regulated. In this …
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HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells
Deacetylation of non-histone substrates by histone deacetylase 6 (HDAC6) has been shown to affect chemotactic invasion (e.g., Haggarty et al., 2003; Hubbert et al., 2002; Tran et al., 2007) or wound healing motility (Lafarga et al., 2012) of fibroblasts. Chemotactic invasion and wound-healing …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… to replace or reduce the use of current ones. Histone deacetylase 6 (HDAC6) plays a variety of biologic functions in a number of important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a …