Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Histone acetyltransferase"”.
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Experimental and computational methods for identification of novel fungal histone acetyltransferase Rtt109 inhibitors
Rtt109 is a fungal-specific histone acetyltransferase that catalyzes histone H3 lysine 56 acetylation and is a promising antifungal drug target. To identify novel Rtt109 inhibitors as potential drug scaffolds, we employed in vitro high throughput screening (HTS) and various computer-assisted …
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Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
… tract in ATXN7, a component of the SAGA histone acetyltransferase (HAT) complex. Previous studies provided conflicting evidence regarding the effects of polyQ-ATXN7 on the activity of Gcn5, the HAT catalytic subunit of SAGA. Here I showed that reducing Gcn5 expression accelerates both …
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EXPRESSION OF HISTONE DEACETYLASE 4 AND HISTONE ACETYLTRANSFERASE 4 IN HUMAN MASSETER MUSCLE: RELATIONS TO FIBER-TYPE COMPOSITION IN PATIENTS WITH MALOCCLUSIONS
… expression of the chromatin modifying enzymes histone deacetylase-4 (HDAC4) and histone acetyltransferase-4 (MYST4) and expression of myosin heavy chain (MyHC) genes and fiber-type percent occupancy (%Occ) in masseter muscle of patients undergoing orthognathic surgery to correct severe …
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Analyzing Post Translational Modifications on Yeast Core Histones Using Fourier Transform Mass Spectrometry
… to study the kinetics of autoacetylation for the histone acetyltransferase, p300."
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The effects of histone acetylation on the maize allele PL1-blotched
Covalent modifications of DNA and nucleosomal histone proteins associated with eukaryotic chromatin have the potential to alter expression of a gene without change in its DNA sequence. One gene regulated through this so-called epigenetic process is the Pl1- Blotched gene of maize. Pl1-Blotched is a …
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HOOKLESS1 REGULATES RESPONSES TO PATHOGENS AND ABSCISIC ACID THROUGH INTERACTION WITH MEDIATOR18 AND ACETYLATION OF WRKY33 AND ABI5 CHROMATIN
Arabidopsis histone acetyltransferase HLS1 has been implicated in the control of seedling development in response to ethylene. Here, we demonstrate that the loss of function hls1 mutant plants have broad effects on the plant development such as early senescence and flowering, seed insensitivity to …
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Studies of the Molecular Features of Brd4-Nut and P300 That Contribute to Condensate Formation and Transcriptional Regulation
… the molecular features of Brd4-Nut and a histone acetyltransferase (HAT), p300, and analyzed their contribution to condensate formation and transcriptional changes. I determined that a minimal fragment of Nut (MIN) in fusion with Brd4 is necessary and sufficient for binding to p300, and …
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The Novel Regulation of Histone Modification In Cancer Development
<p>Dynamic changes in histone acetylation by various physiological cues play important roles in gene transcription and cancer. However, the cellular signaling underlying this regulation is not well understood. Here, we show that, in a glucose dependent manner, E3 ubiquitin ligase NEDD4 …
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Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… proceed gastrulation, and report that GCN5, a histone acetyltransferase (HAT) essential for embryonic development, is required for proper expression of multiple genes encoding components of the FGF signaling pathway, and for normal activation of ERK and p38 downstream of FGF signaling at early …
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Mechanism of Action of ING4 as a Transcriptional Coactivator of p53
… these variants were required to recapitulate the histone acetyltransferase activity of the endogenous complex. Using these complexes, I demonstrate that the ING4 complex histone modifying activity is not directly affected by p53 but is rather indirectly modulated through p53-dependent p300 …
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The Role of E2F1 In The Response to Dna Double Strand Breaks
… found E2F1 status affects foci formation of the histone acetyltransferase GCN5 in response to DNA double-strand breaks. E2F1 is phosphorylated at serine 31 (serine 29 in mouse) by the ATM kinase as part of the DNA damage response. To investigate the importance of this event, our lab developed an …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… This effect was accompanied by POU1F1-dependent histone acetylation and methylation throughout the minichromosome LCR/hGH-N domain. A series of in vitro DNA binding experiments revealed that POU1F1 binds to multiple sites at HSII, consistent with a direct role in HSII function. These observations …
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The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells
<p>Diverse histone modifications such as acetylation, methylation, and phosphorylation play important roles in transcriptional regulation throughout eukaryotes, and recent studies in yeast also have implicated H2B ubiquitylation in the transcription of specific genes. However, a systematic study of …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… genes is regulated by association of DNA with histone proteins into a chromatin complex. Chapter 1 reviews the transcriptional mechanisms involved in the memory formation, including the contribution of chromatin modification by acetylation of histone proteins. Mutating the histone …
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Role of epigenetics in hematopoietic stem cell development
… groups to deoxyribonucleic acid (DNA) and histone proteins, whereas erasers remove them. Readers are groups on transcription factors which interpret these changes and increase or decrease the recruitment of transcriptional machinery accordingly. In this study, a screen of 12 different …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
… with SWI/SNF chromatin remodeling complex, GCN5 histone acetyltransferase, and components of TFIID. These results indicate that full-length E2 may function as a transcriptional activator not only by directly recruiting components of the general transcription machinery to the promoter, but also by …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to chromatin and to acetylate the histone substrates. However, the molecular mechanisms underlying the regulation of these processes are not fully …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… pSSA3-RFP), including the mutants of the HDA1 histone deacetylase (HDAC) complex, suggesting the involvement of histone acetylation in the regulation of starvation-induced gene expression. In the second result chapter, the HDA1 complex was found to be the only HDAC in yeast that acts to …
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STAT3-protein interactions in IL-6/gp130 signaling
… by p300, another coactivator of STAT3 with histone acetyltransferase activity (HAT). The p300-STAT3 interaction is partially regulated by the STAT3 NH2-terminal domain. The second part of this thesis investigates the STAT3 NH2-terminal function and how its interaction with p300 regulates …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… level. Comparative genomics suggests that histone modification-related genes are under positive selection in this species, and polymorphisms in these genes have influenced the adaptation of this species to the human host environment.<br/>Analyses conducted in this project suggest that …
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