Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"Histone acetylation"”.
-
The search for small molecule inhibitors of histone acetylation
Histone acetylation is a key mechanism of transcriptional regulation, which is mediated by two sets<br/>of enzymes; HATs and HDACs. Under normal physiological circumstances there is an orchestrated<br/>balance between the actions of HATs and HDACs. Disruption of this balance can lead to a …
-
Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… to bind to chromatin and to acetylate the histone substrates. However, the molecular mechanisms underlying the regulation of these processes are not fully understood.</p> <p>Through combination of various biochemical, biophysical and molecular approaches, we show that the ZZ-type zinc …
-
The effects of histone acetylation on the maize allele PL1-blotched
Covalent modifications of DNA and nucleosomal histone proteins associated with eukaryotic chromatin have the potential to alter expression of a gene without change in its DNA sequence. One gene regulated through this so-called epigenetic process is the Pl1- Blotched gene of maize. Pl1-Blotched is a …
-
Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… genes is regulated by association of DNA with histone proteins into a chromatin complex. Chapter 1 reviews the transcriptional mechanisms involved in the memory formation, including the contribution of chromatin modification by acetylation of histone proteins. Mutating the histone …
-
Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… pSSA3-RFP), including the mutants of the HDA1 histone deacetylase (HDAC) complex, suggesting the involvement of histone acetylation in the regulation of starvation-induced gene expression. In the second result chapter, the HDA1 complex was found to be the only HDAC in yeast that acts to …
-
Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… level. Comparative genomics suggests that histone modification-related genes are under positive selection in this species, and polymorphisms in these genes have influenced the adaptation of this species to the human host environment.<br/>Analyses conducted in this project suggest that …
-
Epigenetic Changes in Alzheimer’s and Huntington’sS Disease : A semi-quantitative analysis of histone changes
Histone acetylation is an epigenetic mechanism that plays a critical role in the regulation of gene transcription, DNA damage repair and DNA replication. Histone acetylation homeostasis is maintained by a balance in the activity of histone deacetylases (HDAC) and acetyltransferases. Disruption in …
-
Acetyl-CoA metabolism and human trophoblast differentiation
… an enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic modifications. The hypothesis was that ACLY is essential for maintaining trophoblast stemness by providing a localised supply of acetyl-CoA for histone acetylation, thus leading …
-
Histone modifications and the Arabidopsis thaliana circadian clock
… or involved in light responses. Rhythmic histone acetylation has been demonstrated in the promoter of TIMING OF CAB EXPRESSION1 (TOC1). Here, I used semi-quantitative Reverse Transcriptase Polymerase Chain Reaction (semi-quantitative RT -PCR) to investigate which enzymes are involved in …
-
Studies on the mechanisms of action of the male specific lethal complex in Drosophila
… the autosomes to the X chromosome, including the histone acetylase MOF, to nullify the overexpression of autosomal genes but allows this effect to act on the X chromosome. The X linked genes in males are up-regulated twofold to reach the level of two X chromosomes in females. To investigate the …
-
Epigenetic Mechanisms in Blast-Induced Neurotrauma
… mechanisms, including DNA methylation and histone acetylation, are important processes by which cells coordinate neurological and cellular response to environmental stimuli. To date, the role of epigenetics in BINT remains largely unknown. To test this hypothesis, an established rodent …
-
Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… my dissertation, I examined the role of enhancer histone acetylation in neuronal activity-regulated gene transcription. I applied quantitative single-molecule fluorescence in situ hybridization to measure neuronal activity-induced gene transcription at the single neuron level, taking advantage of …
-
Isolation and characterisation of histone transacetylases
Acetylation, one of the post-synthetic modifications of histones, weakens histone-DNA interactions and may play a regulatory role in gene control of eukaryotes. The literature available on histone acetylation as well as other post-synthetic modifications of histone has been reviewed. Histone …
-
Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
… of important metabolic genes. Here we show that histone deacetylase 3 (HDAC3) is recruited to the mouse liver genome in a circadian manner. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Diurnal recruitment of HDAC3 corresponds to the …
-
Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
… cells. SCFAs are chemically related to histone acylations, a growing number of post-translational modifications that include histone acetylation, butyrylation and crotonylation. Histone post-translational modifications are thought to be involved in the regulation of gene expression as …
-
Molecular mechanisms of Kruppel-like Factor 4
… gene IAP, resulting in increased histone acetylation. On the negatively regulated gene, Cyclin B1, I demonstrate that KLF4 recruits HDAC3, decreasing histone acetylation. In addition, I show that KLF4 is acetylated by p300/CBP, and that acetylation of KLF is important in the …
-
MOLECULAR REGULATION OF ATP-CITRATE LYASE
… and is also the essential substrate for protein acetylation. In the nucleus, acetyl-CoA is used for histone acetylation, which is particularly sensitive to glucose availability and ACLY deficiency. ACLY protein is present in both the cytosol and nucleus, but the significance is unclear since …
-
Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as other chemical moieties. Recent evidence points to a possible role for epigenetic mechanisms in …
-
The Novel Regulation of Histone Modification In Cancer Development
<p>Dynamic changes in histone acetylation by various physiological cues play important roles in gene transcription and cancer. However, the cellular signaling underlying this regulation is not well understood. Here, we show that, in a glucose dependent manner, E3 ubiquitin ligase NEDD4 …
Page 1 of 4