Global ETD Search
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Showing 1 to 13 of 13 for “"Histone Post-Translational Modifications"”.
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Proteomic Identification of Histone Post-Translational Modifications Induced By Dna Double-Strand Breaks and Novel Proteins Involved In The Dna Damage Response
… of unbiased systems for identifying proteins and post-translational modifications (PTMs) involved in DSB repair. In this work, we established a novel method, termed DSB-ChAP-MS (Double Strand Break-Chromatin Affinity Purification with Mass Spectrometry), for the affinity purification of a …
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A CELL CYCLE CLOCK REGULATES THE EPIGENETIC LANDSCAPE OF AML CELLS AND DETERMINES SENSITIVITY TO LSD1 INHIBITION
… of cell cycle manipulation, focusing on modifications of the epigenome. Our ATAC-seq investigations show that extension of the G1 phase alters chromatin accessibility. The epigenomic remodeling is further characterized by ChIP-seq and mass spectrometry experiments on genomic distribution …
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Epigenetics of Neurodegeneration: Quantification of Histone Deacetylase Isoforms and Post-translational Modifications of Histones in Alzheimer’s Disease
Histone post-translational modifications have been implicated in many biological functions and diseases and serve an important role in epigenetic regulation of gene expression. Aberrant modulations in histone post-translational have been suggested to occur in the brain as part of Alzheimer’s …
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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… turns of DNA wrapped around an octamer of core histone proteins composed of four histone species: one histone H3/H4 tetramer and two histone H2A/H2B dimers. Histones are basic globular proteins rich in lysine and arginine residues, with unstructured N-terminal "tail" regions protruding outside …
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Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
… cells. SCFAs are chemically related to histone acylations, a growing number of post-translational modifications that include histone acetylation, butyrylation and crotonylation. Histone post-translational modifications are thought to be involved in the regulation of gene expression as …
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MET-2 and SET-25 have sexually dimorphic effects on chromosome structure in Caenorhabditis elegans
… that mutations in different genes involved in histone post-translational modifications have distinct impacts on oocyte and spermatocyte bivalent length. A mutation of set-25, a histone methyltransferase converting histone H3 lysine 9 dimethylation (H3K9me2) to trimethylation (H3K9me3), reduces …
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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin
<p>Histone post-translational modifications modulate chromatin structure and function either by directly altering the intrinsic physical properties of the chromatin fiber or by nucleating the recruitment and activity of a host of transacting nuclear factors. Histone ubiquitylation is one class of …
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A histone H4 code regulates 53BP1-mediated responses to DNA damage
Individual histone post-translational modifications have been implicated in regulating many cellular events. Modifications can occur at high densities in the N-terminal tail domains of core histones, enabling the possibility that combinations of modifications regulate chromatin processes …
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
Histone Post-Translational Modifications (PTMs) are key epigenetic players in physiology and disease, generating a complex combinatorial code that regulates gene expression, nuclear functions and chromatin organization. Aberrant levels of histone PTMs are recognized as general hallmarks of cancer …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… levels of genes through both DNA methylation and histone post translational modifications (PTM). DNA methylation occurs when a methyl group is attached to the DNA strands generally at a cystine residue followed by a guanine. This phenomenon is generally associated with gene silencing, as genes …
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Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as other chemical moieties. Recent evidence points to a possible role for epigenetic mechanisms in …
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
… and is essential for mammalian development. Histone tail post-translational modifications modulate the recruitment and activity of DNMTs. In particular, the PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 lysine 36 trimethylation (H3K36me3). In this study, I …
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Bioinformatic methods for the analysis of genetic variability and regulation
… relationship between the epigenome, particularly histone post-translation modifications (PTM), and regulation of functional genomic elements. Histone marks control much of the workings of the genome. However, it remains unclear how different histone PTM combine within individual nucleosomes to …