Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Histone Methylation"”.
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Zika Modulates Arthropod Histone Methylation in Mosquito Cells
… gene expression, and protein function. Methylation is one such epigenetic modification that involves the addition of chemical modifying entities, such as methyl groups, on nucleic acids or proteins. Recent studies have reported that Zika virus (ZIKV) modulates methylation of human and …
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Histone Methylation and ubiquitination as epigenetic regulators of plant development.
Τα φυτά προσαρμόζονται συνεχώς στο περιβάλλον τους ανταποκρινόμενα σε διάφορα εγγενή και εξωτερικά σήματα. Αντιμετωπίζουν πολυάριθμες βιοτικές και αβιοτικές πιέσεις, όπως ακραίες θερμοκρασίες, ξηρασία ή παθογόνα, που απαιτούν πολύπλοκους ρυθμιστικούς μηχανισμούς για τον έλεγχο της γονιδιακής …
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An investigation into the significance of histone methylation in various mouse tissue
Histone lysine methylation is a post synthetic modification that occurs on the N-terminal tails of histones H3 and H4. This modification occurs at very specific residues, which have been highly conserved throughout evolution. It has been postulated that histone methylation may be involved in the …
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The Polycomb Complex 2 contributes to developmental delay when histone methylation is inappropriately inherited
<p>Histone methylation is a post-transcriptional modification to the N-terminal tails of histone core proteins that regulates DNA accessibility, and consequently, gene expression. Like DNA, histone methylation can be inherited between generations, and is highly regulated during embryonic …
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The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
… regulating the expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisites for Myc-induced transcriptional activation. DOT1L is the only known histone methyltransferase that catalyses mono-methylation …
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Fasting alters histone methylation in paraventricular nucleus of chick through regulating of polycomb repressive complex 2
… reversible epigenetic imprints left on the histones [6,7,8], especially during the prenatal and postpartum period [9]. Histones are highly dynamic and responsive towards environmental stress [10,11]. Through covalent modification of the histone tail, histones are able to direct DNA …
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Role of Chromatin Structure and JmjC Histone Demethylases in the Response to Hypoxia
… these changes remains largely unknown. Global histone methylation changes occur in response to hypoxia, however, temporal dynamics of histone methylation changes and how they correlate with hypoxia induced gene transcription changes is ill defined. The Jumonji C (Jmjc) histone demethylases are …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… is mediated by G9a catalyzation of repressive histone methylation marks at sarcomeric gene promoters. It also associates with MEF2C, a transcription factor essential for sarcomere gene expression, and enhances the interaction with co-repressor HDAC5. This occurs through blocking of calcium …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… in vivo and furthermore, led to the reduction of histone methylation in bone marrow derived macrophages. This discovery suggests that FhHDM-1 can uniquely regulate the trained immune response; a phenotype of immune memory that underpins human immune-mediated diseases. Thus, this PhD project has …
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
… phosphorylation of EMERIN and possibly affects histone methylation. Here, we propose a novel mechanism by which Mena may regulate metastasis during SCC progression.
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… of BRAF<sup>V600E</sup> mutation and DNA hypermethylation suggests this is a unique subgroup harboring aberrant epigenetic phenotype. Firstly, DNA methyltransferase (DNMT) inhibitor treatment induced profound DNA hypomethylation in vivo, but minimal change in gene expression due to adaptive …
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WDR5 Network Analysis Using Ensemble Approaches
… interactions are significant for regulation of histone methylation and consequently epigenetic regulation. These interacting partners include the SET1 family of proteins and retinoblastoma binding protein-5 (RbBP5). In this work we used multiple ensemble measurement based bulk-phase techniques …
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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… turns of DNA wrapped around an octamer of core histone proteins composed of four histone species: one histone H3/H4 tetramer and two histone H2A/H2B dimers. Histones are basic globular proteins rich in lysine and arginine residues, with unstructured N-terminal "tail" regions protruding outside …
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Investigations into the molecular regulation of gene expression in airway smooth muscle cells
… In particular it has been shown that specific histone modifications demarcate functional and architectural regions within the genome. Investigations using chromatin-immunoprecipitation followed by next-generation sequencing (ChiP-seq) to generate a profile of histone methylation enrichments …
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Dissecting the function and targets of FOXG1 in glioblastoma
… and key regulators of both DNA and chromatin methylation, including TET3 and CHD3. Pharmacological inhibitors of MYC block FOXG1-driven de-differentiation, whereas Vitamin C and 5-azacytidine – agents that disrupt DNA and chromatin methylation – can facilitate de-differentiation. CRISPR/Cas …
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Histone modification and the epigenetics of X chromosome inactivation
… of ways, including the hypoacetylation of core histones, a common property of genetically inactive chromatin. This study has used Xi to explore the functional significance of hypoacetylation and patterns of histone methylation in silent chromatin. Xi was shown to be depleted for di- and …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… factor prolyl-hydroxylases (PHDs) and on DNA and histone methylation. Chapter V focuses on the role of glutarate in cellular metabolism and reveals that glutarate controls the activity of the pyruvate dehydrogenase complex (PDHc) via the post-translational modification glutarylation. The final …
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Histone modifications and the Arabidopsis thaliana circadian clock
… or involved in light responses. Rhythmic histone acetylation has been demonstrated in the promoter of TIMING OF CAB EXPRESSION1 (TOC1). Here, I used semi-quantitative Reverse Transcriptase Polymerase Chain Reaction (semi-quantitative RT -PCR) to investigate which enzymes are involved in …
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Establishment of the epigenetic landscape in mammalian embryonic stem cells
Temporal and spatial variation of histone methylation is an important factor in mammalian development. Deciphering the details of such epigenetic phenomena has the potential to enrich both stem cell biology and therapeutics, as well as offer insight into various pathologies. While the enzymatic …
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
… that are read, written, and erased on DNA and on histone protein, which package our DNA. The writing and erasing of epigenetic marks requires metabolic products including but not limited to, acetyl-CoA, methionine, and NAD+. Consequently, cell metabolism, epigenetic regulation, and cell phenotype …
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