Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"Histone Deacetylases"”.
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Roles of Class II Histone Deacetylases in the Cardiovascular System
Histone acetylation/deacetylation, which is orchestrated by two opposing families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs), represents one of the fundamental mechanisms to control gene transcription. Class II histone deacetylases regulate developmental and …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
<p>The inhibitors of histone deacetylases (HDACs) have shown promising neuroprotective and neuroactive properties. A set of pan- and isoform-specific HDAC inhibitors were evaluated for neurotrophic activity on Neuroscreen-1 (NS-1) cells, a subclone of PC-12 (rat pheochromocytoma) cells. </p> <p>The …
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Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
… ist die Acetylierung und Deacetylierung von Histonen. Diese Histon-Modifikationen spielen in der epigenetischen Regulation der Genexpression eine entscheidende Rolle. Die Acetylierung von Histonen erfüllt spezifische Funktionen und kann durch Umweltreize moduliert werden. Dieses Konzept wird …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… in obesity. Thus, the modulation of epigenetic histone modifications and microRNA functions represents a potentially powerful approach for the treatment of metabolic disorders. We show that the Ppargc1b gene, which encodes the PGC-1β protein, also co-transcribes two microRNAs, miR-378 and …
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Targeting Histone Deacetylases (Hdac) For The Treatment of Soft Tissue Sarcoma
<p><strong>Targeting Histone deacetylases (HDAC) for the </strong><strong>treatment of genetically complex soft tissue sarcoma</strong></p> <p>Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of …
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The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
Histone acetylation/deacetylation is a dynamic process that coordinates proper gene expression through the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors continue to show promise in a multitude of pathological settings such as cancer and …
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The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
… their investigation as anticancer drugs, histone deacetylase inhibitors were identified as having anti-inflammatory actions, leading to further studies into how histone deacetylases may be involved in cytokine regulation. However, despite the importance of appropriate histone deacetylase …
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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… Newer approaches include the utilization of histone deacetylase (HDAC) inhibitors. It has been observed that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such as the HER2 mRNA, though the mechanism underlying this process remains undefined. Earlier observations in our …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… by methyl binding domain proteins (MBDs) and histone deacetylases (HDACs), is essential for mammalian development, with the nervous system demonstrating particular sensitivity to perturbations. Little is known, however, about the role of DNA methylation in the stage-specific differentiation of …
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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… utilized fission yeast to study the roles of the histone deacetylases (HDACs) Sir2 and Clr3 in heterochromatin formation and cancer associated mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by …
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Molecular and Genetic Analysis of Novel Epigenetic Silencing Factors Dhp1, Lsd1, and Lsd2
… gene SPAC25G10.01, Rix1 complex member Ipi1, and histone deacetylases Lsd1 and Lsd2. We are however able to identify previously unreported genetic interactions between SPAC25G10.01Δ and mutants of histone deacetylases Clr3 and Sir2. We also generate novel lsd1 and lsd2 mutants for these analyses, …
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N⁶-formylation of lysine : a pathological secondary modification of proteins
… lysine is an abundant endogenous modification of histone and chromatin proteins. The high abundance of N⁶-formyllysine in histone proteins and its chemical similarity to the biologically important N⁶- acetyllysine has raised questions about its mechanisms of formation and biological consequences. …
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Strategies for targeting cancer: small molecules, epigenetics and drug design
… the most recent status of drugs developed using histone deacetylases (HDAC) and histone deacetylases inhibitors (HDACi) for targeting specific cancers. And in my final chapter of SET-domain proteins, my research focused on comparing the methyltransferase activity inhibition of SMYD3 in two …
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… for normal development to occur. Class I histone deacetylases (Hdacs), including Hdac3, play critical roles in regulating gene transcription, through both epigenetic and non-epigenetic means. In this dissertation, I use mouse genetics to explore the previously undescribed role of Hdac3 in …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… associates with Gsc which in turn recruits histone deacetylases to negatively regulate Mixl1 expression during early mouse development. Post-translational modification of transcription factors by SUMO proteins represents an important mechanism through which their activity is controlled. …
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Dissecting the Multifaceted Relationship Between Maize and Cochliobolus carbonum race 1
… race 1 (CCR1) utilizes HC-toxin, an inhibitor of histone deacetylases, as a key determinant of virulence. The maize Hm1 gene confers complete resistance to CCR1 at all stages of development by encoding for an NADPH-dependent reductase that inactivates HC-toxin. Hm1A, Hm1-SM1, and Hm1-SM2 are …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
Histone deacetylases (HDACs) are important regulators of developmental processes and cellular functions. However, their role in hematopoiesis has not been determined, and in Xenopus laevis, a specific function for HDACs has yet to be identified. In the present work, we employed the class I …
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Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches
… Receptor Co-Repressor 1 (NCOR1) complexes with Histone Deacetylases (HDACs) to repress the action of unliganded NRs, hence, inhibiting their transcriptional and phenotypical effects. NCOR1 was found to be over-expressed in PC-3 cells when compared to non-malignant RWPE-1 cells. Chemical …
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The role of E2f4 in cell cycle exit and bone development
… phase of the cell cycle. These complexes recruit histone deacetylases to target gene promoters to prevent the transcription of genes required for cell cycle progression. As cell cycle exit is often concomitant with differentiation, it is not surprising that mutation of the E2Fs and pocket proteins …
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