Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Histone Deacetylase (HDAC) Inhibitors"”.
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The structural requirements of histone deacetylase (hdac) inhibitors: suberoylanilide hydroxamic acid (saha) analogues modified at c3, c6, and c7 positions enhance selectivity
<p>Histone deacetylase (HDAC) proteins are targets for drug design towards the treatment of cancers since overexpression of HDAC is linked to cancer. Several HDAC inhibitors, including the FDA approved drug suberoylanilide hydroxamic acid (SAHA, Vorinostat), have cleared clinical trials and emerged …
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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… Newer approaches include the utilization of histone deacetylase (HDAC) inhibitors. It has been observed that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such as the HER2 mRNA, though the mechanism underlying this process remains undefined. Earlier observations in our …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… via chromatin remodeling, and treatment with histone deacetylase (HDAC) inhibitors relieves this repression leading to activation of TTP expression. Taken together, our novel findings provide strong evidence for the protective role of TTP in cervical and intestinal epithelium that originates …
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Characterization of a Novel NPC1I1061T Knock-in Mouse Model of Niemann-Pick Type C1 Disease
… for the NPC1<super>I1061T</super> mutation. Histone deacetylase (HDAC) inhibitors have also been shown to augment NPC1<super>I1061T</super> protein and cholesterol egress from the lysosome, possibly via an increase in HSP90 expression. Together, these findings raise the possibility that small …
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EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
… the lytic reactivation potential to histone deacetylase (HDAC) inhibitors and generated preclinical data supporting the use of HDAC inhibitors and the anti-viral ganciclovir for treatment of EBV+ epithelial tumors. Lastly, I have identified modulators of the response to a PI3Ka …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… cell lines. This led to the identification of histone deacetylase (HDAC) inhibitors as promising candidates, as they exhibited low IC50 values with a clear reduction in cell viability. To investigate these findings, the final chapter details the results of a custom HDAC inhibitor library (53 …
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Investigating the pathogenesis and therapy of Friedreich Ataxia
… silencing of the FXN gene accompanied by histone changes, flanking the GAA repeats. This suggested potential therapeutic use of compounds which can reduce the methylation and increase the acetylation of histone proteins. Therefore, using human and mouse primary fibroblast cell lines I have …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… cells and non-metastatic prostate cancer cells. Histone deacetylase (HDAC) inhibitors or silence of endogenous HDAC1 and HDAC2 markedly elevated P-Rex1 transcription in non-metastatic prostate cancer cells, whereas overexpression of recombinant HDAC1 in metastatic prostate cancer cells suppressed …
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Genistein suppresses colon cancer metastasis through epigenetic regulations
… regulations, including DNA methylation and histone modifications, both in vitro and in vivo. But there is lack of critical data indicating the epigenetic mechanisms of metastasis prevention potentials of genistein. Because of the known functions of genistein in the suppression of cancer …