Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 956 for “"Histone"”.
-
Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6
Histone H3 lysine 36 (H3K36) trimethylation is a conserved post-translational modification critical for maintaining eukaryotic transcriptional fidelity and genomic stability. This modification is catalyzed in yeast by Set2, an ortholog of the mammalian H3K36 methyltransferase SETD2. Several studies …
-
HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… Ddc2, the Ddc1 component of the 9-1-1 complex, histone H2A. Another Mec1 target is adaptor Rad9. Phosphorylation of Rad9, followed by its oligomerization, allows the recruitment and activation of the effector checkpoint kinase Rad53. This is a key step in the signal transduction cascade; it can …
-
Using "Designer" Nucleosomes to Study Enzymatic Crosstalk Between Histone Ubiquitylation and Histone Methyltransferases
… affecting all types of DNA metabolism. Histone proteins in particular are extensively post-translationally modified (PTM), and many of these individual modifications have been studied in depth. I have been interested in how the complex repertoire of histone PTMs are co-regulated to …
-
The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes
… chromatin. Key regulators of these processes are histone binding proteins known as histone chaperones. The histone chaperone complex Chromatin Assembly Factor 1 (CAF-1) is responsible for depositing H3.1/H4 tetramers in a DNA synthesis dependent manner. During replication independent assembly …
-
Histone Modifications in Trypanosoma Brucei
… at inactive ES. In other organisms, the role of histone posttranslational modifications (PTMs) in influencing transcriptional states has been well-documented. To begin to understand the role of chromatin structure in the regulation of gene expression in trypanosomes, I developed a protocol for …
-
Metabolic Regulation of Gene Expression through Differential Histone Acylation: The Regulation and Function of Histone Crotonylation
<p>Histone lysine acetylation (Kac) plays a critical role in gene regulation by affecting the accessibility of the DNA wrapped around histones and by recruiting effector complexes. Three major classes of proteins are associated with Kac, namely "writers," enzymes that covalently modify specific …
-
Studies on the Histone Methyltransferase G9a
… such mechanism is the association of DNA with histones to form chromatin, the physiological substrate of gene expression. An important means by which histones impact transcriptional activity is through site-specific enzymatic modification of the amino terminal histone "tails", which can alter …
-
Isolation and characterisation of histone transacetylases
… one of the post-synthetic modifications of histones, weakens histone-DNA interactions and may play a regulatory role in gene control of eukaryotes. The literature available on histone acetylation as well as other post-synthetic modifications of histone has been reviewed. Histone acetylation …
-
The reconstitution of the histone octamer
… chicken erythrocyte octamer from acid-denatured histones or the natural H3-H4 tetramer and H2A-H2B dimers. Oligomeric properties of reconstituted octamers were elucidated during column chromatographic and chemical cross-linking studies. The conformational identity of the natural and reconstituted …
-
Mechanistic Insights into the Stimulation of Dot1L-Mediated Methylation of Histone H3 by Semisynthetically Ubiquitylated Histone H2b
<p>Post-translational modification of histones plays an integral role in regulation of chromatin-templated processes through modulation of chromatin structure and function. One such modification, ubiquitylation of histone H2B on lysine 120 (uH2B), has been correlated with enhanced methylation of …
-
Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
Discovery of Isozyme Selective Histone Deacetylase Inhibitors.
-
Carboxyl Methylation of Non-Histone Chromosomal Proteins
<p>The <u>in vitro</u> methylation of non-histone chromosomal proteins (NHCP) was investigated in nuclei isolated from the brain, liver, and thymus of 6-8-day-old rats. After incubating the nuclei in the presence of 20 μM S-adenosyl-L-[methyl-<sup>3</sup>H]methionine(l Ci/mmol), the NHCP were …
-
Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… turns of DNA wrapped around an octamer of core histone proteins composed of four histone species: one histone H3/H4 tetramer and two histone H2A/H2B dimers. Histones are basic globular proteins rich in lysine and arginine residues, with unstructured N-terminal "tail" regions protruding outside …
-
EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… involving enzymes, such as members of the histone deacetylase (HDAC) family, in particular those belonging to class I and class II, which modulate post-translational modifications on target proteins. The current knowledge on HDACs is that they function in general as transcriptional …
-
Histone Deacetylase 1: Mutagenesis And Small Molecule Studies
<p>Histone deacetylase 1 (HDAC1) has been linked to cell growth and cell cycle regulation, which makes it a widely recognized target for anticancer drugs. The 14 Å channel of Class 1 HDAC isotypes has long being hypothesized to be the exit cavity for acetate following deacetylation. The amino acids …
-
Control of Regulatory Element Function by Histone H3.3
In eukaryotic cells, DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. While chromatin functions in part to organize a large amount of genomic material within the confines of the nucleus, regulatory DNA sequences consequently become masked to …
-
Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… requires the post-translational modification of histones and results in the extracellular release of chromatin. The extracellular chromatin incorporates histones in which arginines have been converted to citrullines by peptidylarginine deiminase IV (PAD4) creating structures that capture or …
-
Regulation of Histone Covalent Modifications During Yeast Apoptosis
… structure is the covalent modification of histones, which associates with DNA to form the nucleosome, the fundamental unit of chromatin. Phosphorylation of histone H2B at serine 14 (H2BS14ph), catalyzed by Mst1 kinase, has been linked to chromatin compaction during mammalian apoptosis. I …
-
Exploring Histone Modifying Complexes with a Proteomic Approach
… 4 in Histon H3 und ist die erste, entdeckte Histone H3 Lysin 4 Methyltransferase. Es beinhaltet ein Ash2 Homolog (Bre2), einen bekannten Baustein von trxG. Kürzlich wurden Rad6 beinhaltende Komplexe gezeigt, die in engem Bezug zu der H3-K4 und H3-K79 Methylation durch ubiquitinierung von …
Page 1 of 48