Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Histiocytic sarcoma"”.
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
This work provides a review of canine histiocytic sarcoma (HS) including background immunology, diagnosis, treatment, and prognosis. Given the poor prognosis of HS compared to other soft tissue sarcomas in dogs, the research performed focuses on diagnosis including immunohistochemistry (IHC), the …
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Evaluation of the microenvironment and immune function in histiocytic sarcoma, a tumour of dendritic cells
Canine histiocytic sarcoma (HS) is a highly aggressive tumour of histiocytic origin and it accounts for up to 50% of malignant tumours in flatcoated retrievers (FCR). Effective treatment has yet to be found, and prognosis is always poor. In recent years, in human and veterinary oncology, there has …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
Histiocytic sarcoma (HS) is an exceptionally rare malignant neoplasm derived from dendritic cells and histiocytes, with no available effective treatment options. Akt signaling and proteasome dysfunction have been implicated in the pathogenesis of the disease, both in humans and dogs. Our work aims …
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Insights into determinants of cancer susceptibility, initiation, and progression:studies on medulloblastoma and Histiocytic Sarcoma in mouse models
… Chapter three discusses a mouse model of Histiocytic Sarcoma (HS) that was developed to identify genes that can contribute to initiation and cause progression of disease. The genetics of HS are not well understood. Our model could provide important information on molecular targets that can …
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… and lymph node metastases; one dog had cubital histiocytic sarcoma with spleen metastases; and one had soft palate fibrosarcoma. Treatment of all six dogs was associated with minimal side effects, was easy to perform, was associated with repair of bone lysis in cured dogs; improved the quality …
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Investigations into the role of inflammation in tumorigenesis
… explore this complicated role with a focus on histiocytic sarcoma (HS) and breast cancer. Chapter 1 opens with a broad overview of inflammation in tumorigenesis while Chapter 2 focuses on a review and discussion of current HS literature. Our investigations into the role of inflammation …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis (MCT). Lymphoma is one of the most common cancer types affecting dogs and humans, and therefore, novel therapeutic approaches are always needed. For all of these cancer …