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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 412 for “"Histidine"”.
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Targeting Receptor-Histidine Kinase Signaling in Staphylococcus Aureus
… signaling systems involving receptor-histidine kinases (RHKs) are present in all branches of life outside of the animal kingdom. Remarkably, very little is known concerning the extracellular ligands that presumably bind to RHKs to initiate signaling. The two-component agr signaling …
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Assimilation of N¹⁵-histidine in amino acid imbalance
An attempt was made to isolate L-N¹⁵-histidine from Escherichia coli cultured in a defined medium containing nitrogen-15 enriched ammonium salts as the only source of nitrogen. Commercially prepared L-N¹⁵-histidine.HC1.H₂0 was used to follow the limiting amino acid in the imbalanced diet in rats …
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ANTIMICROBIAL ACTIVITIES OF HISTIDINE-RICH GLYCOPROTEIN AND CATIONIC PEPTIDES
… that replacement of lysine and arginine by histidine in the consensus motifs abrogated the antibacterial effects of these peptides. Antibacterial effects of the histidine-rich consensus peptides were restored by the addition of Zn2+ or low pH. Similar results were obtained with …
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Investigating the polyphosphate interactome with lysine- and histidine-rich proteins
… modification (KPM). Amidst studying histidine polyphosphate modifications (HPM), proteins with repeating lysine residues emerged as plausible polyP targets. Screening within yeast, human, and bacterial proteomes revealed 19 novel KPM target proteins. Much like HPM, KPM exhibits …
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Control of Ligand Binding to Heme Proteins: The Role of The Distal Histidine
We have investigated the effect of the distal histidine on the recombination rates of CO and O(,2) to sperm whale myoglobin, separated beta chains of normal human hemoglobin and to the beta chains of hemoglobin Zurich. The recombination was measured using flash photolysis from 300 to 40 K, on a …
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Control of ligand binding to heme proteins: The role of the distal histidine
We have investigated the effect of the distal histidine on the recombination rates of CO and O2 to sperm whale myoglobin, separated beta chains of normal human hemoglobin and to the beta chains of hemoglobin Zurich. The recombination was measured using flash photolysis from 300 to 40 K, on a time …
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Predicting and testing determinants of histidine-kinase functions by leveraging protein sequence information
… networks in bacteria is a pair of proteins, a histidine kinase and a response regulator. Upon receiving an input signal, a histidine kinase autophosphorylates and then catalyzes transfer of its phosphoryl group to a cognate response regulator, which often activates a transcriptional response. …
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Modulation of Antibacterial Activity and Cytotoxicity in Amphipathic Cyclic Peptide [R4W4] Using Histidine Substitution
… studies, it was observed that substitution with histidine (H) into a tryptophan (W) and arginine (R) rich AMP resulted in a strong modulation of cell cytotoxicity.</p> <p>In this study, we designed and synthesized four cyclic peptides ([W3HR4], [W4H3R], [W4H2R2], and [WH3R4]), in addition to the …
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Myoglobin at pH 3: Dynamics of myoglobin with the iron-proximal histidine bond broken
… co-workers have shown that in Mb the proximal histidine (F8) protonates, causing the histidine-iron bond to break with a pK of 3.45. We measured the rebinding kinetics of CO to myoglobin (Mb) at pH3 in 75% glycerol/water in the Soret from 10K to 300K and 50 ns to 100 s. Below about 200K, the …
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Effect of a histidine-tryptophane-ketoglutarate solution on coagulation as measured by a thromboelastogram
Background: The Histidine-tryptophan-ketoglutarate (HTK) solution is cardioplegic solution that confers myocardial protection during periods of ischemia in heart surgery. It has the advantage of allowing a longer protection and it is especially the preferred cardioplegic solution in complex …
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The preparation of the coordination compounds of platinum (II) and arginine, histidine, lysine, and serine
… and four alpha-amino acids, namely arginine, histidine, lysine, and serine. A first analysis of the problem would seem to indicate that the preparations should be straightforward and not difficult. Bailar (3) stresses the great coordination tendency of the alpha-amino acids. Secondly, …
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Azotobacter vinelandii nitrogenase: role of the MoFe protein α-subunit histidine-195 residue in catalysis
… residue-195 position, normally occupied by a histidine residue, was individually substituted by a variety of other amino acids. Structural studies have revealed that this histidine residue is associated with the FeMo-cofactor binding domain and probably provides an NH→S hydrogen bond to a …
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The determination of the reactivity of the histidine residues of sperm whale met-myoglobin with bromoacetate
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Effect of Heavy Metals on the Uptake of L-Histidine by the Polychaete Nereis Succinea
Integumentary uptake of 3H-L-Histidine by Nereis succinea was measured in the presence and absence of selected heavy metals and inhibitors in 60% artificial seawater (ASW). At low concentrations of L-Histidine (10 uM), metals stimulated L-Histidine uptake from ASW. Higher concentrations of metal …
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Project Synthesis of N Acetyl L Histidine Ethyl Amide and Standard Operating Procedure for Fractional Collector
… Studies show that tryptophan, tyrosine and histidine side chains gives rise to semi stable peroxides on exposure to singlet oxygen these oxidized structures are studied with low temperature NMR. These peroxides or species derived from them have been postulated as key intermediates in …
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Role of the Nla6S and Nla28S histidine kinases in fruiting body development of <i>Myxococcus xanthus</i>
… changes in gene expression. They contain a histidine kinase sensor that detects environmental cues and a response regulator that modulates cellular processes. Two key regulators of the early stages of fruiting body development are the Nla6S/Nla6 and Nla28S/Nla28 TCSs. The response regulators …
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Molecular and Biochemical Analysis of the Histidine Kinase CusS and its Role in Metal Resistance in Escherichia coli
… reactions between the prototypical histidine kinase CusS and the response regulator CusR. Copper sensing by the periplasmic domain of CusS is proposed to initiate signal transduction in the Cus system. Despite the frequency with which bacteria employ histidine kinases to sense their …
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