Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Hirschsprung Disease"”.
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… in various congenital abnormalities, such as Hirschsprung disease (HSCR). In HSCR, neurons are absent from variable lengths of the gastrointestinal tract due to a failure of neural crest cell (NCC) colonization or development, leading to megacolon and/or the failure to pass meconium. Enteric …
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RET Mediated Gene Expression and Cell-Migration
… RET mutations are associated with development of Hirschsprung disease, which is characterized by a lack of mature ganglia in the gut. Conversely, activating RET mutations are associated with several thyroid cancers. Papillary thyroid carcinoma is frequently associated with sporadic translocations …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
Hirschsprung disease (HSCR) and chronic intestinal pseudo-obstruction (CIPO) are life-threatening bowel motility disorders that cause growth failure, abdominal distention, and sometimes, early death. In HSCR, the enteric nervous system (ENS) does not develop completely, resulting in a region of …
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An analysis of neonatal mortality following gastro-intestinal and/or abdominal surgery in a tertiary hospital in South Africa
… (3%) and intestinal failure associated liver disease (1%). Most neonates (69%) who died were prematurely born. Mean age at surgery was 10 days (median 6 days; interquartile range (IQR) 3-16) and mean age at death was 6 days (median 5 days; IQR 2-12; range 1-30). Nearly all patients who died …