Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 100 for “"Hippocampal neurons"”.
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Detection of SK2 Channels on Hippocampal Neurons
… precise spatial organization of SK channels in neurons has remained unknown. Such knowledge is critical as the subcellular distribution of SK channels is an important determinant of neuronal excitability. Currently, there are no techniques to image ion channel distribution quantitatively at the …
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Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
cAMP beeinflusst sekretorische Prozesse sowohl durch Protein Kinase A (PKA)-abhängige als auch durch PKA-unabhängige Signaltransduktionsprozesse. Dennoch ist der jeweilige Anteil an einer cAMP-vermittelten Regulation der Neurotransmission nur unzureichend bekannt. In verschiedenen Preparationen von …
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Uncovering Zn2+ and Ca2+ Homeostasis and Crosstalk in Primary Hippocampal Neurons
… for the first time, we revealed that developing neurons fire spontaneous and synchronous Zn<sup>2+</sup> spikes at a specific time window (from 14 to 25 days in vitro (DIV)) without external stimuli. By blocking Ca<sup>2+</sup> influx from voltage-gated Ca<sup>2+</sup> channels (VGCCs) and …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… the main sites of synaptic input onto excitatory neurons. As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local stimulation …
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Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… death by blocking calcium entry into the neurons using calcium channel blockers or NMDA receptor antagonists have failed to provide any beneficial effects in clinical trials. Thus, calcium continues to enter the neurons despite the presence of calcium entry blockers. This phenomenon is …
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miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
… billion computers, you had eighty-six billion neurons. Instead of men laying down the wiring on pre-programmed routes, the wires had to grow on their own. And instead of the lands and seas of Earth, you had to achieve all this in the space of a single human skull. This is the self-organization …
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Synaptic and extrasynaptic NMDA receptors in hippocampal neurons: regulation of nuclear shape and cell fate
… induces morphological changes in the majority of hippocampal neurons by forming infoldings of the nuclear membrane. These infoldings are generated by an increase in the surface area of the nuclear membrane and require activation of the ERK-MAP kinase cascade as well as a nuclear calcium signal. …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
The locations and dynamics of glutamate synaptic receptors—the AMPA receptors (AMPARs) and NMDA receptors (NMDARs)—located on the postsynaptic membrane of nerve cells, are crucial for neuronal health, learning and memory formation. They can exist under basal condition where no synaptic strength …
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WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… in the membrane fraction of WWC2 KO hippocampal tissue, suggesting that WWC2 regulates GABAAR recycling. These changes to receptor expression and trafficking are specific for GABAARs, as WWC2 KO animals have unchanged expression of AMPAR subunits GluA1 and GluA2. I further make use of …
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When to learn and when to forget : NMDA normalization in hippocampal neurons-- activity-dependent, temporal and spatial properties.
Synaptic plasticity is the substrate of a vast variety of learning mechanisms. However, the molecular pathways and physiological patterns that regulate it are poorly understood. In the first part of this thesis, we focus on the physiological determinants of pre-synaptic plasticity. We find that a …
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Multifractal Complexity of Hippocampal Memory Processing
… activity patterns within ensembles of hippocampal neurons. Fractals, omnipresent in biological and physical systems, often manifest when systems are iterative or reverberatory, and consequently are detectable in spike trains of hippocampal neurons. This dissertation focuses on …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… expression specifically in postnatal, forebrain neurons recapitulates many of the phenotypes seen in human patients. These findings, among others, lead to interest in MeCP2's function in the brain. Our research has focused on the transcriptional repression activity of MeCP2 and its role in the …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… signaling. This thesis demonstrates that in hippocampal neurons, NCAM2 is co-expressed with the insulin and IGF1 receptors during the peak period of synaptogenesis. NCAM2 colocalizes with the active insulin and IGF1 receptors in developing and mature neurons. In NCAM2-deficient neurons and …
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Novel Optical Tools to Investigate Presenilin Control of Neurotransmission
<p>Neurotransmission is a critical function for neurons that underlies the complex processes of the brain. Deficits in synaptic function often manifest in neurodegenerative diseases, motivating the study of control points of neurotransmission. The Endoplasmic Reticulum (ER) has recently been …
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2D and 3D patterning of molecules and cells
… for high throughput patterning and analysis of Hippocampal Neurons on glass. Cell adhesive synthetic Poly-L-Lysine patterns are built juxtaposed from a non-adhesive silane background and control the distribution and growth of Hippocampal Neurons. Results from large scale patterning and analysis …
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Role of Neuroligin in Synapse Formation and Autism
… more potently promotes synapse formation in hippocampal neurons, whereas neuroligin 1 lacking splice site B, which binds both alpha - and beta -neurexins, is more efficient at synapse expansion. Mutations in two surface loops of neuroligin 1 abolished neuroligin binding to neurexin 1beta and …
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The effects of hyperglycaemia on neuronal mitochondria
Neurons depend on mitochondria more than any other cell type for their growth and survival. Mitochondria are known as the main powerhouse of the cell because of their important metabolic functions. Through the processes of the electron transport chain (ETC) and oxidative phosphorylation, …
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… the proper cumulative functioning of billions of neurons. This accumulation of neuronal function requires a sophisticated network between neurons with neuronal axons sending signals and neuronal dendrites typically receiving them. The plastic nature of the brain requires this network to be first …
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