Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"Hippocampal Formation"”.
-
Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… changes, researchers have concentrated on the hippocampal formation, a medial temporal lobe structure involved in the regulation of mood and cognition in humans. It is now clear that estradiol increases the substrates of hippocampal synaptic plasticity, including dendritic spine density, …
-
Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… oscillations associated with epileptic seizure. Hippocampal sharp-wave ripples are observed in CA1 during inactivity and slow-wave sleep, and thought to be important for memory reconsolidation. Using optogenetic light ramp stimuli in transgenic mice, I found that gradual depolarization of CA1 …
-
Tracking The Flow of Information Through The Hippocampal Formation In The Rat
… exact mechanisms by which it codes and stores information is an unresolved topic. This work examines the flow of information through the hippocampal formation while attempting to determine the computations that each of the hippocampal subfields performs in learning and memory. The formation, …
-
Investigating the role of the hippocampal formation in episodic and spatial memory
… explore the two dominant functional roles of the hippocampal formation, in the relational encoding of episodic memory and the neural representation of allocentric space, using a combination of pharmaceutical manipulations and single-unit recording techniques in rodents. The first part of this …
-
Functional dissociation between the hippocampal formation and perirhinal cortex : evidence for independent memory systems in the medial temporal lobe
… lobe of the mammalian brain suggest that the hippocampal formation (HPC) and the perirhinal cortex (PRh) are serial components in a unitary memory system. Contradictory to this view, evidence from numerous studies with monkeys and rats suggest that there are at least two independent memory …
-
Searching for knowledge. The neurophysiology behind the exploration of hippocampal cognitive maps.
… is crucial for animals’ survival. Neurons in the hippocampal formation support spatial exploration through locomotion, and eye movements in primates, as well as memory. However, how the hippocampus supports exploration across different cognitive domains remains unclear. In this thesis I will …
-
The effects of chronic ethanol self-administration on the serotonin system in monkeys
… in part by modulating neuroplasticity in the hippocampal formation. The hippocampal formation plays a key role in excessive alcohol consumption through its involvement in the neurocircuitry responsible for the reinforcing effects of alcohol and its role in acquiring alcohol-related memories. …
-
ΑΝΟΣΟΚΥΤΤΑΡΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΤΟΥ ΑΓΓΕΙΟΚΙΝΗΤΙΚΟΥ ΠΟΛΥΠΕΠΤΙΔΙΟΥ ΤΟΥ ΕΝΤΕΡΟΥ, ΤΗΣ ΧΟΛΗΚΥΣΤΟΚΙΝΙΝΗΣ ΚΑΙ ΤΟΥ ΝΕΥΡΟΠΕΠΤΙΔΙΟΥ Υ ΣΤΟ ΚΕΝΤΡΙΚΟ ΝΕΥΡΙΚΟ ΣΥΣΤΗΜΑ, ΤΟΥ ΣΚΑΝΤΖΟΧΟΙΡΟΥ ΚΑΙ ΤΟΥ ΠΡΟΒΑΤΟΥ
… BRAIN STRUCTURES SUCH AS CEREBRAL CORTEX, HIPPOCAMPAL FORMATION, HYPΟTHALAMUS, CENTRAL GRAY SUBSTANCE OF THE MIDBRAIN BOTH IN THE HEDGEHOG AND THE SHEEP. IN THE CEREBRAL CORTEX VIP- NEURONS WERE LOCATED IN ALL LAYERS BUT WERE CONCENTRATED IN LAYERS II AND III. THE MAJORITY OF THEM WERE …
-
Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
… and the subgranular zone (SGZ) in the hippocampal formation. A variety of stimuli such as voluntary exercise, epileptic seizure activity and inflammation can affect the basal level of neurogenesis. In the course of pathological conditions such as Alzheimer’s disease, multiple sclerosis, …
-
Circuitry and function of layer 1 interneurons in the medial entorhinal cortex
… neural processing must occur in the hippocampal formation. In this region of the brain, a number of different cell populations exhibit spatially modulated firing patterns. One area in particular, called the medial entorhinal cortex (MEC), contains a high density of spatially-tuned …
-
Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
… found that hypothyroidism results in decreased hippocampal NGF levels, while up-regulating its receptors: the p75 neurotrophin and p140 trk A receptor. We propose that declining levels hippocampal NGF results in decreased trophic support for basal forebrain cholinergic neurons, leading to a …
-
Measuring Memory in an Alzheimer's Treatment Trial Using a Visual Search Task
… memory deficits attributed to damage to the hippocampal formation. AD therapies specifically targeting hippocampal function may be best evaluated through the use of selective hippocampal tasks. I used a nonverbal hippocampal-dependent target-in-scene detection task to determine if task …
-
The Influence of Aging and Parkinson’s Disease on Neural Oscillations Associated with Memory Consolidation
… high-frequency oscillations, or ripples, in the hippocampal formation are required for the conversion of short-term to long-term memory. These ripples couple to two slower oscillations found in the cortex, delta waves and spindles. The author describes here his contributions to the field of …
-
Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
… more relevant, soluble form of Aβ induces the formation of cofilin-actin rods within neurons. Rods may grow to occlude the neurite and block transport, leading to loss of microtubules and synapses. Tau is a microtubule binding protein whose hyperphosphorylation depends upon its release from …
-
Neuromodulation by endogenous Interlukin-1β in hippocampus of the murine brain: Regulation of neuronal excitation
… on granule neurons of the dentate gyrus of the hippocampal formation and that dysfunction of this brain region can shift the E/I balance toward excitation, my research focused on the possibility that constitutive IL-1β signaling in the hippocampal formation modulates brain E/I balance. The …
-
Mnemonic Representations of Transient Stimuli and Temporal Sequences in the Rodent Dentate Gyrus In Vitro
… in processing, maintaining, and recalling information. The ability to maintain information for a short period of time is known as working memory, and behavioral experiments in vivo have highlighted the role of persistent neural activity in several brain regions, including the hippocampus, in …
-
Septotemporal Variation in Theta Rhythm Dynamics: Effects of Speed and Habituation
… potentials present neural network indices of hippocampal physiology. Theta signals within the hippocampal formation may reflect alterations in sensorimotor integration, the flow of sensory input and/or distinct cognitive operations. While the power and coherence of theta signals vary across …
-
Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… of intraneuronal Aβ and tau was observed in the hippocampal formation, amygdala, and entorhinal cortex, and at late stages (18 months), extracellular amyloid plaques and NFTs, primarily in the subiculum and the CA1 layer of the hippocampal formation. Increased activity of Akt, detected with …
-
Hippocampal output to neocortex: Examination of the electrophysiological and plastic properties of CA1 projections to the perirhinal cortex
The hippocampal formation is an important structure in learning and memory that is required for the transfer of sensory information into long-term storage. This long-term storage is believed to occur in the neocortex and the physiological mechanism underpinning this transfer of information is …
-
Examination of Molecular Mechanisms Underlying Developmental and Adult Learning-Associated Plasticity in the Rat Brain
… cerebral cortex and in the CA1 subfield of the hippocampal formation. Flatmap 1 did not show a learning induced response. The results presented in this thesis strongly implicate Fos and related antigen expression in neuronal differentiation and suggest possible involvement in adult motor …
Page 1 of 2