Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 674 for “"Hippocampal"”.
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Stress and Hippocampal Plasticity
… alterations are reversible, suggesting that the hippocampal system experiences a certain degree of plasticity in response to stress. This dissertation examines the effects of chronic restraint stress on several parameters of hippocampal plasticity, including dentate gyrus neurogenesis, polysialic …
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Automated hippocampal location and extraction
… that is able to first locate and then extract hippocampal volumes from 3D 1.5T MRI T1 brain scans automatically. The hybrid algorithm uses brain atlas mappings and fuzzy inference to locate hippocampal areas and create initial hippocampal boundaries. This initial location is used to seed a …
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Timing and hippocampal information processing
Timing is a key component in hippocampal encoding of space. I will discuss three lines of work related to this theme. First, I will describe the fine-timescale characteristics of single neurons in hippocampal subregion CAl, where theta oscillations organize groups of neurons into orderly sequences. …
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Multifractal Complexity of Hippocampal Memory Processing
… activity patterns within ensembles of hippocampal neurons. Fractals, omnipresent in biological and physical systems, often manifest when systems are iterative or reverberatory, and consequently are detectable in spike trains of hippocampal neurons. This dissertation focuses on …
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Dopaminergic modulation of hippocampal neural circuitry
… those receptors and triggering the effects on hippocampal physiology. The VTA/SNpC innervation density in the hippocampus is modest and, in many cases, the axons are distant from the neurons exhibiting the effects. Other sources of DA could couple to those receptors, such as the locus …
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Mechanisms of hippocampal relational memory binding
… the statistical structure of its inputs, hippocampal interleaved learning can only prevent interference in the neocortex to the degree that it creates artificial structure via temporal ordering and repetitive exposure. In a modeling context, it is of course always possible to tune the …
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Hippocampal microcircuits for social memory specification
… specification). Recent studies have implicated hippocampal sub-region dorsal CA2 (dCA2) in social recognition and identified social recognition memory engram in downstream ventral CA1 (vCA1). However, the anatomical site for the storage of social specification memory and its underlying …
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Detection of SK2 Channels on Hippocampal Neurons
<p>Calcium-activated small conductance potassium channels (SK) are crucial for synaptic plasticity, sleep, and learning and memory (Hammond, Bond et al. 2006; Cueni, Canepari et al. 2008; Lin, Lujan et al. 2008). Despite the recent progress on SK channel physiology, the precise spatial organization …
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Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis
… in psychiatry, I show (Chapter 4) that each hippocampal subfield in schizophrenia has a unique molecular identity based on its transcriptome profile. As well, I show only slight effects of antipsychotic medication on schizophrenia-dependent gene changes in DG, CA3, and CA1. Taken together, my …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
… the effects of the VTA-dopamine system on hippocampal synaptic transmission are largely under-explored and the underlying mechanisms are unclear. The goal of this project was to investigate mechanisms involved in dopaminergic modulation of hippocampal neurophysiology. Specifically, I (1) …
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Latent variable models for hippocampal sequence analysis
Place cell activity of hippocampal pyramidal cells has been described as the cognitive substrate of spatial memory. Indeed, the activity of ensembles of neurons within the hippocampus is thought to enable memory formation, storage, recall, and even decision making. Replay is observed during …
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An Electrophysiological Study of Thalamo-Hippocampal Relationships
… functions (Green and Arduini, 1954), and hippocampal potentials have been recorded following stimulation peripherally (visual, acoustic, gustatory, somatosensory, and other kinds of stimuli; Ungiadze, 1968), or stimulation of the cortex and of various subcortical structures (MacLean, 1967; …
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Impact of adult hippocampal neurogenesis on behavior
The role of adult hippocampal neurogenesis in behavior, especially contextual fear conditioning (CFC), is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe impairment. We sought to determine …
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Old-age hippocampal sclerosis in the aged population
Old-age hippocampal sclerosis (HS), characterised by severe neuron loss in hippocampal CA1, is a poorly understood cause of dementia. At present no objective pathological HS criteria exist. In life HS is commonly diagnosed as Alzheimer's disease. HS aetiology is unclear, although it has been …
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The temporal and bilateral structure of hippocampal replay
… of replay is investigated at the levels of hippocampal sharp-wave ripples and multi-unit activity. We found that, during sleep, ripples generation is modulated by a 10-15Hz rhythm. We also observed this rhythm in the multi-unit firing rate of hippocampal neurons. Next we investigated and …
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