Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Hippo signalling"”.
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies have shown that there is aberrant nuclear activity of yes-associated protein (YAP) and …
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The TAZ Protein Interactome in Striated Muscle
Hippo signalling is a prominent regulator of cell proliferation, differentiation, and death. Previously, we characterized the Hippo transcriptional effector TAZ as a repressor of the myogenic differentiation program. Without DNA-binding ability, TAZ function exclusively depends on its …
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… coordinated intercellular communication via signalling pathways, mechanisms underlying intestinal morphogenesis remain unclear. The Hedgehog signalling pathway is critical for many aspects of gut development, however, its downstream transcriptional targets allowing for complex cell behaviours …
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Defining novel targets and functions of the protein kinase DYRK2
… cell differentiation, but they also orchestrate signalling responses to nitrosative, oxidative, nutritional, heat and osmotic stress. The five mammalian DYRKs can be divided into two subgroups based on their sequence homology: class I (DYRK1A, DYRK1B) and class II (DYRK2, DYRK3, DYRK4). …
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Exploring the Potential use of TEAD Inhibition as Part of a Combination Therapy for NF2-Deficient Schwannoma and Meningioma.
… with TEAD inhibition, to target aberrant Hippo signalling and secondary resistance mechanisms. We utilised immortalised and primary cells to evaluate the efficacy and potential synergism of TEAD inhibitors VT3989 and VT107 in combination with brigatinib. Further preclinical in vivo …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… The loss of Merlin function causes augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… and NSC biology. In *Drosophila*, insulin signalling is necessary and sufficient for the reactivation of NSCs from quiescence, a conserved state of mitotic dormancy. InR has been observed in the nucleus of a range of cell types *in vitro* for decades, but it is only more recently that the …
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Exploring the Role of Long Non-Coding RNA in Neural Stem Cell Reactivation from Quiescence: A Functional Genomics Approach
… and accessibility of genes associated with Hippo signalling, ribosome biogenesis, mitochondrial energetics and cell cycle regulation—key processes implicated in NSC reactivation. This work demonstrates that pron acts in trans to regulate the expression of a suite of genes involved in …
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Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery
… replication such as the PI3K, MAPK, TNF and WNT signalling pathways but also revealed novel functional associations including that of the Hippo signalling pathway. Intriguingly pathway analysis revealed an enrichment for host factors associated with viral carcinogenesis and a convergence on host …
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Global alterations of the epigenetic landscape define endometrial receptivity and provide a hallmark for endometriosis
… particularly prevalent at genes involved in the Hippo signalling pathway, which regulates core aspects of cell and tissue biology including cell polarity, adhesion, proliferation and apoptosis. These epigenetic changes may potentially predispose endometrial cells of endometriosis patients to …