Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Hippo signaling"”.
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Studies of the Hippo Signaling Pathway
… To identify novel components of the Hpo signaling pathway, I carried out a genetic modifier screen in which flies carrying GMR-Gal4 and UAS-Yki were crossed to a collection of transgenic RNAi lines from Vienna Drosophila RNAi center (VDRC) and Bloomington stock center, and looked for …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… the host cell by activating the Wnt and Notch signaling pathways via a novel tandem repeat short linear motif (SLiM). Interestingly, we demonstrate that TRP120 utilizes a Hedgehog SLiM to activate Hedgehog signaling and the Wnt SLiM to mediate Hippo signaling during infection to prevent …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
<p>Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent, non-toxic, and reversible inhibitor of Hippo signaling. An ATP-competitive …
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big bang, a novel regulator of tissue growth in Drosophila melanogaster
… discs, which gives rise to the adult wing. The Hippo signaling pathway regulates tissue growth in wing development. There are several observations that link tissue growth/Hippo signaling with cell polarity and the actin cytoskeletal organization. The aim of this thesis was the study of the …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… inhibit the growth of cancer cells through the Hippo signaling pathway. Ewing’s sarcoma is the second most commonly diagnosed pediatric bone cancer. While there are common forms of general treatment available, there are little to no treatments for recurrent cases, as well as malignant tumors. …
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Genetic modeling of the Hippo pathway in hematopoietic stem cells
… aim of this thesis was to study the role of the Hippo signaling pathway in HSCs. The Hippo pathway is a newly discovered signaling pathway, which regulates organ size in Drosophila. Hippo signaling has further been implicated in regulation of mammalian stem cells. In Article I we developed a new …
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Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
… promoting breast cancer. Recently, downregulated HIPPO signaling was shown to drive the pro-growth effects of IL 6. Reduced HIPPO signaling allows for the nuclear translocation of transcriptional co-activator yes associated protein (YAP), implicating IL-6 in the co-activation of several …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… The loss of Merlin function causes augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
… transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced equilibrium governs …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the balance of cell proliferation and apoptosis and results in epithelial tissue tumorigenesis. The …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… the cellular proliferation network including the Hippo signaling pathway. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously regarded as transcriptional byproducts, function through diverse mechanisms as critical regulators of gene expression and the vital …
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… YAP/TAZ that promote malignancies through the Hippo signaling pathway. We show that VGLL1 may play a significant role in tumorigenesis by inducing tumor cell proliferation, migration, and invasion.</p>
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role in neural crest (NC)-derived heart formation is still largely unknown. We generated <em>Yap </em>and <em>Taz </em>conditional knockout (CKO) mice using a …
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… on pregnancy establishment and embryo-maternal signaling to day 30 of gestation; 4) elucidate how and when FLI regulates embryo development; 5) characterize the necessity for FGFR2, LIFR, and IGF1R for FLI modulation of the developing embryo. Overall, this work illustrated the benefit of FLI …
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Cell Polarity Regulates Organ Growth Through The Hippo Pathway
… of function cause overgrowth and induction of Hippo target genes. In addition, Crumbs is required for the proper localization of Expanded, an upstream component of the Hippo pathway. Furthermore, we uncoupled the cell polarity and growth control function of Crb through structure-functional …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
The Hippo pathway is an evolutionarily conserved signaling cascade and comprises the core Hippo kinases MST1/2 and LATS1/2, which phosphorylate the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly …
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Adherens Junctions and The Actomyosin Network Regulate Organ Growth By Modulating Hippo Pathway Activity In Drosophila
… the downstream transcriptional effector of the Hippo pathway. Importantly, it is unclear if AJ and basolateral components act through the same or parallel mechanisms to regulate Yorkie activity.</p> <p>Here, we dissect how loss of AJ and basolateral components affects Hippo signaling in …
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Evaluating the duration of increased milking frequency during early lactation for increased yield through lactation
… key target investigated was a component of the Hippo signaling pathway, Yes-associated protein (YAP). Intensity of YAP staining in the cytoplasmic area of mammary epithelial cells (MEC) and number of YAP-positive stained nuclei located in the MEC were quantified for each of the images obtained. …
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