Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"Hippo pathway"”.
-
Genetic Analysis of The Hippo Pathway In Mouse Liver
… genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the balance of cell proliferation and apoptosis and results in epithelial tissue tumorigenesis. The …
-
Cell Polarity Regulates Organ Growth Through The Hippo Pathway
… cell polarity coordinates with growth control pathways in developing organs to achieve appropriate organ size remain obscure.</p> <p>To investigate the function of apical determinants in growth regulation, I investigated the mechanism by which the apical determinant Crumbs affects growth in …
-
Analysis of Hippo pathway signalling in schwannoma and meningioma
… The loss of Merlin function causes augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is …
-
Genetic modeling of the Hippo pathway in hematopoietic stem cells
… aim of this thesis was to study the role of the Hippo signaling pathway in HSCs. The Hippo pathway is a newly discovered signaling pathway, which regulates organ size in Drosophila. Hippo signaling has further been implicated in regulation of mammalian stem cells. In Article I we developed a new …
-
Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
<p>The highly conserved Hippo kinase cascade is critical for both regulation of organ size in development and tumor suppression. Several mechanisms, such as cell-cell contact in vitro and organ size in vivo, have been implicated in the activation of the Hippo pathway, leading to inactivation of the …
-
Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
The Hippo pathway is an evolutionarily conserved signaling cascade and comprises the core Hippo kinases MST1/2 and LATS1/2, which phosphorylate the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly …
-
Adherens Junctions and The Actomyosin Network Regulate Organ Growth By Modulating Hippo Pathway Activity In Drosophila
… the downstream transcriptional effector of the Hippo pathway. Importantly, it is unclear if AJ and basolateral components act through the same or parallel mechanisms to regulate Yorkie activity.</p> <p>Here, we dissect how loss of AJ and basolateral components affects Hippo signaling in …
-
Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… developmental and homeostatic processes. The Hippo pathway is a major regulator of tissue growth and organ size. Hippo and TGFβ pathways are intimately interconnected. Hippo pathway mediators Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically …
-
The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies have shown that there is aberrant nuclear activity of yes-associated protein (YAP) and …
-
Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… organ growth as a component of the conserved Hippo pathway, which has been implicated in both tissue size control and cancer development. djub-deficient epithelial tissues were small due to decreased cell numbers resulting from increased apoptosis and decreased proliferation due to the …
-
Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… in the developing mouse brain through the Hippo pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates Yap/Taz is not understood. Here I showed that Nf2 regulated the Yap/Taz activity by decreasing the stability of Yap/Taz. The regulation was …
-
Characterization of the two major merlin isoforms and merlin regulation of YAP
… of the oncogene YAP through stabilization of the Hippo-pathway kinase Lats, allowing Lats to phosphorylate and inhibit YAP. In this thesis I identify an additional mechanism for merlin regulation of YAP, which occurs independently of the Hippo-pathway-based regulation. I show that mesothelioma …
-
Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… motif (TAZ or WWTR1), key players of the Hippo pathway, have been implicated in the liver fibrosis, but the HSC-specific functions of YAP and TAZ are largely unclear. Here we have identified Sirtuin 6 (SIRT6), an NAD+ dependent deacetylase, as a key epigenetic regulator in the protection …
-
The Role of YAP/TAZ in von Willebrand Factor Gene Expression
… coactivators largely known for their role in the Hippo pathway. They function predominantly through interactions with TEAD transcription factors to regulate transcription of target genes, which ultimately execute the physiological output of upstream signalling mechanisms. Mechanical signals, such …
-
Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
… surface, regulating tissue growth through the Hippo pathway and Planar Cell Polarity (PCP) tissue patterning. Ft also enters mitochondria to regulate mitochondrial function and metabolic state. However, the coordination of Ft’s functions remains largely unknown. In the first part of my thesis, …
-
Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… it leads to increased YAP nuclear levels. The Hippo pathway is the main inhibitor of YAP. One component of this signaling cascade,Lats1/2, phosphorylates YAP at Serine 127, thereby promoting its cytosolic retention and degradation.In line with YAP nuclear retention after the treatment, we …
-
Biophysical profiling of YAP/TAZ dependent mechanical responses
… Numerous studies have shown that the Hippo pathway, a well-recognized mechanotransductive cellular pathway, and its downstream transcriptional co-activators, YAP and TAZ, play prominent roles in proliferation, regeneration, and wound healing. Interestingly, these are often found to be …
-
Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… of new therapeutics for GBM. The main Hippo pathway transcriptional coactivators YAP and TAZ are master regulators of up to 70% of the entire glioma stem cell gene signature and so represent key molecular targets in the development of new therapeutic strategies for GBM. However, …
-
YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in
-
Functional Regulation of Yap By Aurora A Kinase In Triple-Negative Breast Cancer
… is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated …
Page 1 of 2