Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Hippo Signaling pathway"”.
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Studies of the Hippo Signaling Pathway
… have identified the Hpo tumor suppressor pathway as a crucial mechanism that controls tissue growth by inhibiting cell growth, proliferation and survival. Deregulation of the Hpo pathway has been implicated in various human cancers. Central to the Hpo pathway is a kinase cassette …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
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A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… inhibit the growth of cancer cells through the Hippo signaling pathway. Ewing’s sarcoma is the second most commonly diagnosed pediatric bone cancer. While there are common forms of general treatment available, there are little to no treatments for recurrent cases, as well as malignant tumors. …
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big bang, a novel regulator of tissue growth in Drosophila melanogaster
… discs, which gives rise to the adult wing. The Hippo signaling pathway regulates tissue growth in wing development. There are several observations that link tissue growth/Hippo signaling with cell polarity and the actin cytoskeletal organization. The aim of this thesis was the study of the …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
… transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced equilibrium governs …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the balance of cell proliferation and apoptosis and results in epithelial tissue tumorigenesis. The …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… the cellular proliferation network including the Hippo signaling pathway. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously regarded as transcriptional byproducts, function through diverse mechanisms as critical regulators of gene expression and the vital …
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… YAP/TAZ that promote malignancies through the Hippo signaling pathway. We show that VGLL1 may play a significant role in tumorigenesis by inducing tumor cell proliferation, migration, and invasion.</p>
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role in neural crest (NC)-derived heart formation is still largely unknown. We generated <em>Yap </em>and <em>Taz </em>conditional knockout (CKO) mice using a …
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Genetic modeling of the Hippo pathway in hematopoietic stem cells
… aim of this thesis was to study the role of the Hippo signaling pathway in HSCs. The Hippo pathway is a newly discovered signaling pathway, which regulates organ size in Drosophila. Hippo signaling has further been implicated in regulation of mammalian stem cells. In Article I we developed a new …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… The loss of Merlin function causes augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is …
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Evaluating the duration of increased milking frequency during early lactation for increased yield through lactation
… key target investigated was a component of the Hippo signaling pathway, Yes-associated protein (YAP). Intensity of YAP staining in the cytoplasmic area of mammary epithelial cells (MEC) and number of YAP-positive stained nuclei located in the MEC were quantified for each of the images obtained. …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… organ growth as a component of the conserved Hippo pathway, which has been implicated in both tissue size control and cancer development. djub-deficient epithelial tissues were small due to decreased cell numbers resulting from increased apoptosis and decreased proliferation due to the …