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Showing 1 to 6 of 6 for “"Hinokitiol"”.
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
… is reached. Previously, we have shown that hinokitiol can perform a protein-like function to replace the missing iron transporters. Its unique ability to perform site- and direction-specific iron mobilization to restore iron homeostasis resulted in physiological restoration in various animal …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… natural product from the bark of Cypress trees, hinokitiol, could leverage built-up iron gradients to restore the movement of iron into, within, and/or out of cells, and restore physiology to the system. Hinokitiol promotes the movement of iron in cells deficient in Fet3Ftr1, DMT1, Mfrn1, or FPN1 …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
… assay, the small molecule natural product, hinokitiol, restored growth to yeast missing the iron transporting complex Fet3Ftr1. Hinokitiol promoted iron uptake, and concomitantly restored cell growth back to wild-type levels. In contrast to water soluble iron chelators, hinokitiol:iron …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… Last, we probed the metal binding affinity of hinokitiol through UV-Vis spectrophotometric titrations and synthesized Hino-TACN ligands as novel metal-chelating fragments. We also proposed the next generation BFCs as molecules that could form neutral 64Cu complexes and have smaller molecular …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
… restore growth. We identified the small molecule hinokitiol (Hino) as capable of restoring growth in yeast lacking iron transporters. We then tested Hino in human colorectal epithelia lacking an iron transporter and observed Hino-mediated restoration of transepithelial iron transport. Together, …
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Minimizing higher-order aggregation maximizes iron mobilization by small molecules
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01