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Showing 1 to 4 of 4 for “"Hindlimb-Unloading"”.
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… Methods: 35 male C57BL/6J mice were assigned to hindlimb unloading (HU), Lewis Lung Carcinoma (LLC), or control groups. HU animals were hindlimb-unloaded for 1 week to induce disuse atrophy. LLC cells were injected into the right hind-flank to induce cancer cachexia. Tumors developed for …
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Skeletal adaptation to reduced mechanical loading
… cues is poorly understood, particularly for unloading. Defining the fundamental mechanoregulation of bone adaptation is critical for the better understanding and mitigation of bone loss in astronauts as well as clinical conditions such as spinal cord injury, stroke, muscular dystrophy, and …
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Skeletal adaptation to reduced mechanical loading
… cues is poorly understood, particularly for unloading. Defining the fundamental mechano-regulation of bone adaptation is critical for the better understanding and mitigation of bone loss in astronauts as well as clinical conditions such as spinal cord injury, stroke, muscular dystrophy, and …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
… male and female C57BL6/J mice were hindlimb unloaded for 24 hours, 48 hours, 72 hours, and 168 hours and were compared to cage control mice. RT-qPCR was used to measure mRNA content of ACVR2B and GRB10 of the gastrocnemius muscle. Results: LLC female mice had ~35% lower ACVR2B mRNA …