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Showing 1 to 1 of 1 for “"HilA modification"”.
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Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… in Salmonella. Proteomic analysis reveal that HilA, a key virulence transcription regulator, is short-chain fatty acylated. I employ Amber Suppression Technology and CRISPR-Cas9 genome editing to faithfully mimic butyrylation on endogenous HilA. Biochemical and functional characterization show …