Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"High-throughput drug discovery"”.
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
… of clinical treatments are heavily dependent on drug testing methods despite the cytotoxic effects these methods might have on the patient. Our lab has previously developed a three layered microfluidic cell array (3D μFCA) to reconstruct the relevantly spatial configuration of tumor and …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… dystrophy. Therefore, we hypothesized that drugs that promote α7β1 integrin expression in muscle could be therapeutic in the treatment of DMD. Utilizing a high-throughput drug discovery chemical screen, we identified SU9516, an adenosine mimetic, as an enhancer of ITGA7 expression, the gene …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
… and quantification. LIPS was optimized for high-content screening (HCS) to identify small molecules, natural compounds, and genetic modulators capable of downregulating PrPC levels. A broad range of chemical libraries, including FDA/EMA-approved drugs and computationally selected candidates, …
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High-throughput plasma nanomanufacturing and its applications
… This dissertation presents a low-cost, high-throughput plasma-based nanomanufacturing process, called simultaneous plasma enhanced reactive ion synthesis and etching (SPERISE), to address the technical challenges in mass producing nanoscale structures, components, and devices. This …