Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 324 for “"High-throughput Screening"”.
-
High Throughput Screening of Aptamers
… an aptamer discovery method we are calling High Throughput Screening of Aptamers (HTSA), which incorporates two additional elements that eliminate the cyclic evolution bottleneck in traditional aptamer discovery methods, and expedite the discovery process with no complex automation required. …
-
High-Throughput Screening Development Using Photonic-Crystal Optical Biosensor
… protein-DNA interactions, and can be used in a high-throughput screening mode to identify compounds that prevent protein-DNA binding. The PC technology is used to detect binding between protein-DNA interactions that are DNA sequence-dependent (the bacterial toxin-antitoxin system MazEF), and …
-
High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
… of PAR and MAR. Toward filling this need, a high-throughput screen was conducted using a fluorogenic substrate to discover an inhibitor of ARH3. A total of 496 primary hits have been identified and will be further studied to validate their ability to inhibit ARH3.
-
Advances in high-throughput screening: better compounds, novel targets, enhanced sensors
High throughput screening (HTS) is the dominant force in modern drug discovery. Through the evaluation of large structure collections, novel drug leads can be rapidly assessed for modulation of medicinally-relevant biological targets. This occurs through the interplay of three intrinsically linked …
-
High Throughput Screening for Small Molecule Interactions with Nucleic Acid Binding Proteins
… networks. Cell network architecture depends on highly regulated nucleic acid binding to determine cell identity, developmental trajectory, environmental response, and homeostasis. These proteins govern all aspects of cancer, from oncogenesis to metastasis, as well as treatment resistance and …
-
In search of Mg battery cathode materials - a migration energy high-throughput screening machinery
… the results and progress of developing a high-throughput migration energy calculation machinery and applying it in search for Mg battery cathode materials. We discuss the key challenge of developing functional Mg battery cathode, and propose to use NEB algorithm in high-throughput …
-
Assay Setup for High Throughput Screening to Identify Novel Efflux Pump Inhibitors against Escherichia coli
Tausta: Maailman terveysjärjestö WHO linjasi vuonna 2014 julkaisemassaan raportissa, että antibioottiresistenssi on todellinen maailmanlaajuinen terveysuhka, jonka vastaiset toimet on käynnistettävä. Uusien antibioottien löytäminen ja kehittäminen Gram-negatiivisten bakteerien aiheuttamiin …
-
COMPUTATIONAL MODELING OF BACTERIAL OUTER MEMBRANES AND DEVELOPMENT OF HIGH-THROUGHPUT SCREENING PLATFORM FOR ANTIBIOTICS
… to antibiotics readily due to their unique highly charged outer membrane. Structurally, the Gram-negative bacteria is highly asymmetric bilayer that comprises of an inner leaflet of phospholipids and an outer leaflet of lipopolysaccharides. Embedded in the bilayer are outer membrane proteins …
-
Development of high-throughput screening assays to identify small molecule inhibitors of Plasmodium falciparum Hsp70-1
… by the shortage of simple, cost-effective screening assays. Heat shock proteins (Hsps) are a special class of molecular chaperones essential for parasite survival and development within the human host. Hsps are also implicated in drug resistance. Hsp70 forms an integral part of the …
-
Development of high throughput screening systems for the efficient production of antibody fragments in Escherichia coli
… However, the production of antibody fragments in high yield for preclinical and clinical trials can be a serious bottleneck in drug discovery. This dissertation describes the development of novel screening systems for isolating antibody fragments and alternatively, E. coli genes, that facilitate …
-
Combinatorial Polymer Synthesis and High-Throughput Screening Technology to Identify Optimal Approaches for Mineralized Tissue Engineering
… recent advances in combinatorial chemistry and high through-put screening (HTS) technology have made available a wider range of potential scaffold materials with diverse properties, as well as new methods to accelerate the process of testing soluble factors or combinations of factors. To this …
-
Rapid High-Throughput Screening Methods for Monitoring Electron Transfer Reactions in Biological Systems and Microalgae Phenotyping
… to the Gibbs free energy of reduction and a highly correlated relationship was found. The assay was then applied to the reduction of metabolites via the oxidation of glucose in an alkaline environment. To exhibit the diverse application of the CL assay, urine of healthy individuals, patients …
-
Expanding the Phase Space of Photons in Matter: From High-Throughput Screening to Atom-by-Atom Engineering
… to engineer the elusive lossless plasmon? Using high-throughput screening, artificial intelligence, and atom-by-atom engineering through density functional theory, we determine the topological prevalence of photonic bands, propose two systems that evade plasmonic losses through the …
-
Development and applications of peptide barcoded nanoparticles for high-throughput screening of mRNA delivery materials in vivo
… predictive power of in vitro assays and the low-throughput and costly nature of in vivo screening approaches. Thus, there is still a need for safe, specific, and potent mRNA delivery materials, as well as higher throughput in vivo screening methods. In this work, we developed a novel in vivo …
-
A novel DNA damage quantification platform enables high throughput screening for genes that impact DNA double strand breaks
DNA is the blueprint of life, and the high fidelity transmission of genetic information from parent cells to progeny is essential for an organism's viability. However, our genomes are constantly being damaged by reactive molecules generated from cellular metabolic processes or introduced from the …
-
FITSelect: An Invention to Select Microbial Strains Maximizing Product Formation from a Single Culture Without High-Throughput Screening
… to achieve a desired cell phenotype. A screening strategy follows the randomized genetic manipulations to select strain(s) with the more optimal phenotype of interest. This screening strategy is often divided into two categories: (i) a growth competition assay and (ii) selection by …
-
Determination of Allosteric Solvent Effects Between Acetylcholinesterase and Mosquito Selective Carbamates: Implications for High Throughput Screening of Insecticides
… N-methylcarbamates producing a high degree of selectivity for Anopheles gambiae acetylcholinesterase (AgAChE) over human AChE. Molecular models suggest alternate conformations (flexibility) of W84 and W431 (Ag numbering) at the hydrophobic subpocket of the AgAChE active site and …
Page 1 of 17