Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"High-Throughput technology"”.
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Augmenting drug process development capacity through applications of lean principles and high throughput technology
The long development lead time and high R&D costs for biologics drugs makes it imperative to eliminate delays and inefficiencies. Limited process development capacity can lead to delays in the availability of life-saving drugs and a large opportunity cost for biopharmaceutical companies. This study …
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Contributions to Statistical Problems Related to Microarray Data
Microarray is a high throughput technology to measure the gene expression. Analysis of microarray data brings many interesting and challenging problems. This thesis consists three studies related to microarray data. First, we propose a Bayesian model for microarray data and use Bayes Factors to …
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Integrative high-throughput study of arsenic hyper-accumulation in Pteris vittata
… in <em>Pteris vittata</em> through high throughput technology and bioinformatics tools. The transcriptome of the <em>P. vittata</em>gametophyte under arsenate stress was obtained using RNA-Seq technology and Trinity <em>de novo</em> assembly. Functional annotation of the …
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Selective Targeting of CYP3A5 Through Chemical and Genetic Approaches
… isoform-selective CYP3A5 inhibitor. We used high-throughput technology to identify clobetasol propionate as capable of selectively inhibiting CYP3A5 enzymatic activity without conferring CYP3A4 inhibition. We further demonstrate the in vitro ability of the compound using a clinically relevant …
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New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional Integration
… Genome Project (HGP) and the increasing usage of high throughput technology. HGP was completed in 2003 and resulted in identifying 20,000-25,000 genes in human DNA and determining the sequences of three billion human base pairs. The information requires huge amount of data storage and becomes …
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High-throughput experimental and computational studies of bacterial evolution
… three chapters, I describe a recently developed high-throughput technology for probing gene function, transposon-insertion sequencing, and its application to the study of functional differences between two important human pathogens, Salmonella enterica subspecies enterica serovars Typhi and …
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Computational Techniques for the Analysis of Large Scale Biological Systems
… we develop novel computational, analytical, and high performance simulation techniques for biological problems, with applications to the yeast cell division cycle, and to the RNA-Sequencing of the yellow fever mosquito. Cell cycle system evolves stochastic effects when there are a small number of …
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Error Correction in Next Generation DNA Sequencing Data
Motivation: High throughput Next Generation Sequencing (NGS) technologies can sequence the genome of a species quickly and cheaply. Errors that are introduced by NGS technologies limit the full potential of the applications that rely on their data. Current techniques used to correct these errors …
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Computational analysis of regulatory networks using genome-scale data
… for molecular biologists. Due to the advent of high throughput technology, it has now become feasible to study regulatory networks at the genomic level. Thus the main aim of this thesis is to characterize regulatory networks using genome-scale data. The first step in gene regulation is …
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Using a barley Nested Association Mapping (NAM) Population to mine wild barley germplasm for crop improvement
… (GWAS) of the HEB-25 population. GWAS relies on high throughput technology, which typically assays single nucleotide polymorphisms (SNPs), together with trait data obtained from experimental observation of plants. In this thesis I describe the results of a GWAS study of the HEB-25 population for …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… resources at the time. With the advent of high throughput technologies such as the single cell RNA sequencing, this thesis revisits the LCMV-APC (DC and macrophage/monocytes) interaction at the in vitro, in vivo and single-cell level. The findings from the in vitro study confirmed the …
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Inferential Methods for High-Throughput Methylation Data
The role of abnormal DNA methylation in the progression of disease is a growing area of research that relies upon the establishment of sound statistical methods. The common method for declaring there is differential methylation between two groups at a given CpG site, as summarized by the difference …
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Deep Learning for Unstructured Data by Leveraging Domain Knowledge
… the social interaction on the Internet and the high-throughput technology in sciences, e.g., chemistry and biology. However, for traditional machine learning algorithms, classifying a text document is far more difficult than classifying a data entry in a spreadsheet. We have to convert the …
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Community Structure Detection in Complex Biological Networks
With the advent of high-throughput technology there has been a large increase in the availability of biological data, such as interaction data of genes, proteins and metabolites. It is therefore necessary to develop ways in which these data can be efficiently modelled and analysed. Networks over a …
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Integrative Modeling and Analysis of High-throughput Biological Data
… to understand biological problems. With current high-throughput technology development, different types of biological data can be measured in a large scale, which calls for more sophisticated computational methods to analyze and interpret the data. In this dissertation research work, we propose …