Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"High-Throughput Screening Assays"”.
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Development of high-throughput screening assays to identify small molecule inhibitors of Plasmodium falciparum Hsp70-1
… by the shortage of simple, cost-effective screening assays. Heat shock proteins (Hsps) are a special class of molecular chaperones essential for parasite survival and development within the human host. Hsps are also implicated in drug resistance. Hsp70 forms an integral part of the …
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Advancing Small Molecule Drug Discovery by Targeting Biomolecular Condensates and Evaluating Novel Chemical Scaffolds
… 2, I describe the development of two alternative high throughput screening assays that robustly report on changes in protein condensation states in response to small molecule condensate modulators, expanding the toolkit available for future condensate modulator screening campaigns. Finally, in …
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Tackling Computational Challenges in High-Throughput RNA Interference Screening
… RNAi for genome-wide loss-of-function phenotype screening while reducing cost and decreasing time. High-throughput RNAi screening (HTS) has been widely accepted and used in a variety of biomedical and biological research projects as the first step to identifying novel drug targets or pathway …
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Statistical Design And Imaging Of Position-Encoded 3D Microarrays
… to cases where the target concentration is high or the time period of the sensing is sufficiently long. The sparse distributions correspond to low target concentrations or short sensing durations. We illustrate our design concept using numerical examples. We replace the photon-conversion …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… can impact CTL lytic capacity, using an unbiased high throughput immunophenotyping screen of murine single gene deletion lines from the Wellcome trust Sanger Institute (WTSI) as part of the 3i consortium. I first optimised the cytotoxicity assay to be used for high-throughput screening, …
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Progettazione, sintesi e valutazione farmacologica di derivati del 4-nitro-7-piperazin-1-il-2,1,3-benzossadiazolo come nuovi ligandi sigma fluorescenti
… di trasduzione del segnale, così come per lo screening di nuovi composti terapeutici. In particolare, il metodo della fluorescenza polarizzata (FP), della fluorescenza di risonanza a trasferimento di energia (FRET) e della fluorescenza a tempo risolto (TRFS), sono emersi come soluzione agli …