Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"High mobility group box 1"”.
-
Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
High mobility group box 1 (HMGB1) is a mobile chromatin protein that can relocate into the external environment and act as a cytokine. HMGB1 cellular release can be passive, by cell necrosis, or active, by living cells after a specific stimulus is received. HMGB1 does not possess a leader sequence, …
-
The functions of RECQ protein-like 4 and high mobility group box 1 in osteoblast-like cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
The roles of nuclear matrix protein 4 and high mobility group box 1 in mediating the osteoblast response to anabolic agents
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
… und pro-inflammatorischen Zytokins High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) nachgewiesen. In Zellkulturexperimenten wurde die Auswirkung von entzündlichem Zellstress auf die Expression der beiden Moleküle und auf Zelltod hin …
-
Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches
… (IL-1β)/IL-1Receptor type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental and clinical evidence showed that endogenous anti-inflammatory mechanisms are not efficiently …
-
LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
High mobility group box 1 (HMGB1) is a chromatin-associated protein that is also secreted from activated immune cells, necrotic cells, and certain cancer cells. Previous studies have described that different patterns of post-translational modification (PTM), particularly acetylation and oxidation, …
-
Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… to vehicle control, resulted in significantly higher cell surface expression of calreticulin (CRT), and high mobility group box 1 protein (HMGB1) in the culture supernatants, both of which are markers for (ICD). Studies with the mEER tumor cells implanted in immunocompetent syngeneic mice …
-
Chemoprevention of Familial Melanoma
… the death pathway is non-apoptotic. Release of High Mobility Group Box-1 protein by MBEH-treated melanocytes and ultrastructural features further confirmed a necrotic death pathway mediated by MBEH. A negative correlation between MBEH-induced cell death and cellular melanin content supports a …
-
Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… gene expression of inflammatory genes, such as High mobility group box 1 (HMGB-1), Tissue Factor (TF), and Interleukin 6 (IL-6), associated with IBMIR. To show the efficiency of combinational, we herein engineered 150 IEQ islets with SA-TM or SA-TM/SA-CD47. Importantly, SA-TM/SA-CD47-engineered …
-
Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… the potential homeostatic role of extracellular high mobility group box 1 (HMGB1) in AECs. HMGB1 is a danger-associated molecular pattern (DAMP) that normally resides in the intracellular compartment, and is released into the extracellular space upon cellular injury, stress or death to …
-
Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… in the aging process. Obesity induced by a high-fat diet (HFD) may reduce renal function. However, the impact of obese on the age-related renal disease is not well understood. Exercise reduces oxidative stress. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury …
-
Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… contentssuch as heat shock protein family or high mobility group box 1 (HMGB1).have been identified. I found substantial accumulation of HMGB1, but not members of heat shock protein family, in OL-bathing media after OGD. OLs expressed HMGB1 in nucleus in vitro and in vivoin uninjured …
-
Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… (miR-122) has shown liver specificity and higher sensitivity than alanine aminotransferase (ALT) and High mobility group box 1 (HMGB1) is an informative and early serum indicator of cell death and inflammatory processes in Paracetamol (APAP)-induced liver injury (APAP-ILI). The mechanistic …