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Showing 1 to 20 of 29 for “"High grade serous ovarian cancer"”.
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Roles of PKR in High Grade Serous Ovarian Cancer
High-grade serous ovarian carcinoma (HGSC) is characterized by dissemination within the peritoneal cavity, a process that critically depends on dynamic regulation of cell adhesion, migration, and invasion rather than primary tumor growth. Protein kinase R (PKR; EIF2AK2) is classically described as …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
<p>High Grade Serous Ovarian Cancer (HGSOC) can be classified by gene copy number signatures into 7 subtypes that have differing prognoses and treatment sensitivities and that show differences in the activities of various signalling pathways. An ongoing clinical study has demonstrated the …
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
The majority of women with ovarian cancer (OC) have advanced disease at diagnosis and 5-year survival rates of less than 25%. Women with stage I disease have significantly better 5-year survival rates of over 90%. Recent large studies using CA 125 and transvaginal ultrasound have failed to improve …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
Ovarian cancer is the most fatal cancer in women with over 60% of patients succumbing to the disease. Mutations in a number of homologous recombination repair genes have been implicated in hereditary ovarian and breast cancer. Specifically, over half of ovarian cancer cases exhibit BRCA-deficiency …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is effective at depleting these tumours, sometimes eliminating all visible disease, however the tumour invariably regrows from surviving tumour cells. Improving treatment depends …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… the tissue architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal …
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Fully Automated Segmentation of High Grade Serous Ovarian Cancer on Computed Tomography Images using Deep Learning
… be used for the fully automated segmentation of high grade serous ovarian cancer. The recent rise of deep learning has pushed the limits of what algorithms can achieve in fields of image analysis, such as the task of segmentation. The field of medical image segmentation has fundamentally changed, …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
High-Grade Serous Ovarian Cancer (HGSOC) is the most prevalent and lethal subtype of ovarian cancer, characterised by significant spatial and temporal heterogeneity, which has been linked to poor survival outcomes. In this challenging landscape, the quest to characterise heterogeneity through …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
Ovarian high-grade serous carcinomas (HGSC) are the most common and fatal histological subtype of ovarian cancer, characterised by late stage diagnosis and high mortality rates. Unfortunately, the majority of patients (> 85%) will develop fatal chemoresistant disease despite multiple lines of …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
HGSOC is the most common and deadly form of ovarian cancer and is characterised by vague symptoms, late diagnosis and a high level of metastasis. While most patients initially respond well to the current standard of treatment – tumour debulking surgery and platinum/taxane combination chemotherapy – …
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ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour …
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Modeling Pathophysiology of Human Fallopian Tube Using Microfluidic Organ-on-Chip Technology
Ovarian cancer is a deadly disease, and most high-grade serous ovarian carcinomas originate from the fallopian tube epithelium. Understanding the early events of ovarian cancer tumorigenesis in the fallopian tube is crucial for the development of future detection and intervention strategies. This …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
… such as diabetic neuropathies and certain cancers including breast cancer and high grade serous ovarian cancer. There are numerous HDAC inhibitors that can inhibit HDAC6. These include Trichostatin A and Vorinostat. Recently there has been a drive towards HDAC6 specific inhibitors due to …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… remain standard of care for many cancer patients, including high grade serous ovarian cancer. It is becoming clear that chemotherapy can initiate adaptive immune responses to the cancer, however, it remains unclear to what extent innate Natural Killer (NK) cells contribute. Using …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
High-grade serous ovarian cancer (HGSC) remains the deadliest gynecologic malignancy due to late-stage diagnosis and high recurrence rates. Current immune checkpoint blockade (ICB) therapies show limited efficacy in HGSC, with no approved immunotherapy options for patients. This is due to an …
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Biophysical approaches to single-cell characterization
High-throughput single-cell RNA-seq (scRNA-seq) is used to describe complex tissues by characterizing transcriptional states of individual cells. Defining a cell’s position, both in regard to tissue margins and its social context, is essential for understanding the intrinsic and extrinsic variables …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
Ovarian cancer is the most fatal gynecological malignancy, with high-grade serous ovarian cancer (HGSC) being the most commonly diagnosed and aggressive subtype. Although HGSC initially responds well to debulking surgery and platinum-based chemotherapy, approximately 80% of patients experience …
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Molecular Determinants of Residual Disease In Ovarian Cancer
<p>The standard treatment for high grade serous ovarian cancer is primary cytoreductive surgery followed by adjuvant chemotherapy. Residual disease followed by surgery is associated with adverse overall and progression-free survival as well as poor response to adjuvant chemotherapy. Accurate …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… significance of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number …
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