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Showing 1 to 20 of 21 for “"High fat meal"”.
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The Metabolic Effects of Low Grade Inflammation on Postprandial Metabolism Following a High Fat Meal
… postprandial metabolism following an acute, high fat (HF) meal to be impaired in mice pre-injected with an inflammatory agonist. To this end, C57BL/6J mice were injected with saline or lipopolysaccharide (LPS, 1μg/kgbw) following an overnight fast and gavaged 2hr post-injection with water or …
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Effect of a Single High-Fat Meal and Vitamins on the Circulatory Response to Local Heat in Koreans and Caucasians
… endothelial function (EF) due to the westernized high fat (HF) dietary lifestyle. Hypertriglyceridemia (HTG) can produce free radicals which reduces the bioavailability of the endothelium derived relaxing factor, nitric oxide (NO). EF, as measured by the blood flow response (BFR) to heat, …
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Estimating intragastric disintegration times of immediate release dose units administered after a high-calorie, high-fat meal using standardized, commercially available equipment and materials
Στόχος της παρούσας εργασίας ήταν η διερεύνηση της χρησιμότητας τυποποιημένου, εμπορικά διαθέσιμου εξοπλισμού και υλικών στην εκτίμηση των ενδογαστρικών χρόνων αποσάθρωσης δοσολογιών μονάδων προϊόντων άμεσης αποδέσμευσης μετά από τη χορήγηση γεύματος υψηλής θερμιδικής αξίας και υψηλής …
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Assessing the impact of tablet crushing, dose, and high-calorie, high-fat meal on vericiguat absorption from the upper gastrointestinal lumen using standardized commercially available equipment and materials
… gastrointestinal transfer system after high-calorie, high-fat meal, BioGIThighcal) χρησιμοποιώντας εμπορικά διαθέσιμα όργανα και υλικά. (2) Με βάση τα επίπεδα του vericiguat που μετρήθηκαν στο παρελθόν στο πλάσμα υγιών ενηλίκων, να αξιολογηθεί η χρησιμότητα του BioGIThighcal στην …
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Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… to contribute toward insulin resistance. High-fat diets reduce human skeletal muscle insulin sensitivity and mitochondrial function. Conversely, endurance training increases insulin sensitivity and enhances mitochondrial performance. Recent evidence in mice has found that central …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… a hindered ability to properly transition from fat oxidation while in a fasted state to carbohydrate oxidation once fed, leading to a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial …
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Value of Raisins for Reduction of Oxidative Stress, Endothelial Dysfunction, and Inflammation in Obesity
… endothelial activation in response to an acute high-fat meal in obese individuals. Seventeen overweight men and women consumed raisins or placebo (264 kcal/d) for 14 d in a randomized cross-over design while following a low-flavonoid, weight-maintenance diet. Four high-fat (53% fat) meals were …
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Effect of acute exercise on postprandial lipemia and biomarkers of endothelial dysfunction and inflammation in normal weight and overweight adolescents
… markers (CRP, IL-6, TNF-α, WBC) following a high-fat meal in NW and OW adolescents. METHODS: 10 NW (BMI: 20.9 ± 1.7 kg.m-2, 15.6 ± 0.7 y) and 8 OW (BMI: 28.3 ± 3.6 kg.m-2, 15.9 ± 0.4 y) adolescent boys underwent two 6h oral fat tolerance tests (OFTT) separated by 7 d. On the evening prior to …
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The Role of High Saturated Fatty Acid Diets on Skeletal Muscle Metabolism and Inflammation
… between metabolic adaptive response to 5 days of high SFA feeding, independent of positive energy balance, and diet-induced agonism of pro-inflammatory pathways. A secondary aim was to determine if the metabolic adaptive response in skeletal muscle to a single, high fat meal was altered by 5 days …
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The Effects of Two Modes of High-Intensity Intermittent Exercise on Postprandial Metabolism
… were given a 75g-oral glucose solution and a high-fat meal two hours following exercise. The postprandial assessment lasted 6 hours. Results of the study showed no significant differences in the TG or glucose concentration compared to rest. There was a significant difference between the total …
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The effects of short, disrupted sleep on metabolic and vascular responses to exercise.
… artery flow-mediated dilation (FMD) after high-intensity interval exercise (HIIE). METHODS: Fifteen men (Age = 31 ± 5 years; BMI = 25.8 ± 2.7 kg/m²; %BF = 21.0 ± 6.2; VO₂ max = 49.1 ± 0.7) participated in 3 experimental conditions: reference sleep (REFSL); reference sleep and HIIE (REFEX), …
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Skeletal Muscle Acetylation in Response to an Acute and Chronic High-Fat Diet
… apoptosis, and more. Metabolic proteins are highly susceptible to acetylation with almost all showing the capacity to be acetylated. Our research, using an obese mouse model fed a chronic high fat diet and a lean control mouse model fed a standard chow diet, showed numerous differences in the …
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Prebiotic supplementation with inulin and exercise influence gut microbiome composition and metabolic health
… intravenous glucose tolerance test (IVGTT), and high-fat meal challenge with skeletal muscle biopsies to evaluate changes in the gut microbiome composition, intestinal permeability, insulin sensitivity and metabolic flexibility, respectively. There were no baseline group differences (all p>0.05). …
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The Effects of Acute Consumption and Chronic Supplementation of Cocoa on Overweight and Obese Adults at Risk of Developing Diabetes
… and incretin hormone responses to a mixed meal challenge compared to a placebo. Second, we hypothesized that 15 g cocoa/day for 4-weeks would reduce gut permeability, attenuate endotoxin response to a high fat meal, improve insulin sensitivity, and improve measures of skeletal muscle …
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The Effects of a 5-Day High-Fat Diet on Skeletal Muscle O-GlcNAcylation
Continual intake of high-fat foods, coupled with limited physical activity, can lead to metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity, insulin resistance, cardiovascular disease, and other chronic diseases. Metabolic flexibility of human skeletal …
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The effects of moderate exercise on measures of postprandial lipemia
… to decrease PP TGs in response to a single, high-fat meal. The current study assessed the effect of a single bout of morning exercise on PP lipids over an entire day with 3 mixed meals of a typical macronutrient composition (34% fat, 15% protein, 51% CHO). Methods. 26 normal weight (NW) …
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Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
… multicenter controlled clinical trial evaluating high dose rifapentine in combination with moxifloxacin. The moxifloxacin pharmacokinetic model, together with a previously published ofloxacin pharmacokinetic model, was used to evaluate the efficacy between moxifloxacin and ofloxacin. Furthermore, …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate balance happens quite rapidly, while fat balance does not. The ability of …
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The Effects of Macronutrient Composition on Oxidative Stress and Inflammation in Overweight and Obese Humans
… were differential effects of a conventional low-fat, high carbohydrate weight loss diet (LF) and the Atkins diet (a popular low carbohydrate, high fat diet (HF)) on oxidative stress and inflammation. We demonstrated that HF raised C-reactive protein (CRP) levels relative to LF in overweight and …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… lipotoxicity caused by an impaired regulation of fat uptake and oxidation is postulated to disrupt insulin signaling and lead to skeletal muscle IR. High dietary saturated fat intake results in reduced basal fat oxidation and a resistance to switching to carbohydrate oxidation during …
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