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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 50 for “"High density lipoprotein (HDL)"”.

  1. Investigating high-density lipoprotein (HDL) subfractions, composition and functionality in people living with HIV

    Hudson, PeterDepartment of Medicine2022

    … distribution, composition, and functionality of high-density lipoprotein (HDL) subfractions are altered in the presence of cardiovascular risk factors. We aimed to explore whether HIV and/or ART modulate HDL subfractions and functionality in a population of people living with HIV (PLWH). Methods: …

    cape-town Repository record

  2. Understanding the relationship between high-density lipoprotein (HDL) subclass distribution and functionality in patients at risk of cardiovascular disease

    Woudberg, NicholasDepartment of Medicine2017

    … include obesity, ethnicity and hypertension. High-density lipoprotein (HDL) has traditionally served as a marker for CVD risk. Latest studies, however, propose that the composition and subclass distribution and the anti-atherogenic function of HDL are more accurate predictors of CVD risk. We …

    cape-town Repository record

  3. THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM

    Bashore, Alexander CusaWake Forest University2018

    … binding cassette transporter A1 (ABCA1) and apolipoprotein M (apoM) both have been shown to influence high density lipoprotein (HDL) metabolism. Hepatic ABCA1, a plasma membrane protein, functions to transport free cholesterol (FC) and phospholipids across the plasma membrane to apolipoproteins, …

    wfu Repository record

  4. Exploring the relationship between shifts in high-density lipoprotein (HDL) particle subclass distribution/functionality and cardiac function in doxorubicin (DOX)-induced cardiotoxicity

    Abrahams, Carmelita BiancaDepartment of Medicine2024

    … with dyslipidaemia, however changes in high-density lipoprotein (HDL) particle subclass distribution, composition and functionality are unknown. We therefore aimed to investigate whether changes in HDL particle subclass distribution, composition and functionality in breast cancer …

    cape-town Repository record

  5. Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1

    Fenske, Sara AnneMassachusetts Institute of Technology2008

    … adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a post-transcriptional, tissue-specific decrease in SR-BI protein level and an increase in total plasma cholesterol carried in …

    mit Repository record

  6. Spontaneous lipid transfers between low density lipoproteins and reconstituted high density lipoproteins

    Bottum, Kathleen MaryUniversity of Illinois at Urbana-Champaign2011

    … important components in the metabolism of low density lipoprotein (LDL) and high density lipoprotein (HDL). Cholesterol spontaneously transfers from LDL to HDL; phospholipid transfer proceeds in the reverse direction. Reconstituted HDL (rHDL) particles were employed in this study. Cholesterol …

    uiuc Repository record

  7. Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

    King, Jonathan ChanDivision of Cardiology2011

    … 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and …

    cape-town Repository record

  8. Cholesterol and egg activation

    Wang, LiMassachusetts Institute of Technology2019

    The high-density lipoprotein (HDL) receptor SR-BI controls the structure and fate of plasma HDL. The SR-BI knockout (KO) females are infertile, apparently due to their abnormal, cholesterol-enriched HDL particles. In this thesis, my colleagues and I examined the growth and meiotic progression of …

    mit Repository record

  9. The Role of Lipid-Free Apolipoprotein A-I and PCPE2 in HDL Metabolism

    Pollard, Ricquita DeAnnWake Forest University2015

    … of this work is to investigate the role of apolipoprotein apoA-I (apoA-I) and procollagen C-endopeptidase enhancer 2 (PCPE2) in high density lipoprotein (HDL) metabolism. ApoA-I comprises ~70 percent of the protein within HDL and has an essential role in cholesterol efflux from peripheral cells …

    wfu Repository record

  10. The role of scavenger receptor B-I in hepatitis C virus attachment and entry.

    Grove, JosephUniversity of Birmingham2009

    … (SR-BI) and Claudin-1. SR-BI is a receptor for high density lipoprotein (HDL), it is predominantly expressed in the liver and steroidogenic tissue. HCV is believed to interact with SR-BI via the viral envelope protein E2, interestingly the SR-BI ligand HDL enhances HCV infection. In this study …

    birmingham Repository record

  11. Cholesterol Lowering Effects of Milk with Added Phytosterols

    Cusack, Laura Kells2012

    … incorporating plant sterols (PS) reduce Low-density lipoprotein (LDL) on average approximately 10%. PS with a higher lipid solubility may promote greater reductions. We examined the cholesterol lowering effect of a novel triglyceride recrystallized phystosterol (TRP). Twenty subjects (mean ± …

    uconn-diss Repository record

  12. Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization

    Seetharam, Divya2010

    … is inversely related to circulating levels of high density lipoprotein (HDL) cholesterol. The atheroprotective nature of HDL is attributed mainly to its role in reverse cholesterol transport (RCT). However, recent reports of human and animal studies have suggested that the atheroprotective …

    utswmed Repository record

  13. Treatment of Hypertriglyceridemia with Omega-3 Fatty Acids: A Systematic Review

    Lewis, Amanda Gloria2004

    … was 29%, total cholesterol (TC) 11.6%, very low density lipoprotein (VLDL) 30.2%, and low-density lipoprotein (LDL) 32.5%. One study found LDLs to increase by 25%. The average increase in high-density lipoprotein (HDL) was 10%. The overall average MQI score was 36% (26%-54%). Many of the RCTs had …

    byu Repository record

  14. Investigating the Role of Standing Blood Pressure Measurement and the Association Between High-Density Lipoprotein and Skeletal Muscle Mitochondrial Function in Pre-Hypertensive Humans

    Giacona, John Michael2026

    … and 2) characterize the associations between high-density lipoprotein (HDL) and skeletal muscle mitochondrial function. Herein, we are the first to observe that standing BP measurements are highly accurate in detecting HTN when compared to seated BP. These findings demonstrate standing BP as a …

    utswmed Repository record

  15. The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes

    Brunham, Liam RobertUniversity of British Columbia2007

    … the rate-limiting step in the biogenesis of high density lipoprotein (HDL) particles. In humans,ABCA1 deficiency results in Tangier disease, characterized by low levels of HDL cholesterol, cellular cholesterol accumulation and increased risk for atherosclerosis. More than 100 coding variants …

    ubc Repository record

  16. CHOLESTEROL ABSORPTION AND TRANSINTESTINAL CHOLESTEROL EFFLUX (TICE) RATES ARE UNALTERED IN MICE OVEREXPRESSING INTESTINAL SR-BI.

    Bura, Kanwardeep SinghWake Forest University2011

    … in the liver by facilitating selective uptake of high density lipoprotein (HDL) cholesterol. Interestingly, SR-BI is also expressed in the small intestine. Previously it has been reported that mice overexpressing SR-BI specifically in the proximal small intestine have accelerated cholesterol …

    wfu Repository record

  17. The Effects of a Multi-Component Wellness Program on Employee Biometrics

    Patrick, Jennifer Erin2019

    … costs. Using five risk factors (blood pressure, high density lipoprotein (HDL-C), triglycerides (TG), fasting blood glucose, and waist circumference) individuals with three or more risk factors are classified as having Metabolic Syndrome. Voluntary pre and post health screenings were conducted at …

    mississippi Repository record

  18. The effect of exercise and the alteration of carbohydrate content of a hypocaloric diet on blood lipids

    Tarlton, Sandra L.Virginia Polytechnic Institute and State University1984

    … combination of an exercise program with either a high carbohydrate (HC) hypocaloric diet or low carbohydrate (LC) hypocaloric diet on total cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides. Subjects were randomly placed in one of the diet groups (530 kcal/day) and …

    vt Repository record

  19. Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency

    Low, J.K.UCL (University College London)2009

    … esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease) LCAT deficiency, the failure to esterify cholesterol causes many cellular and metabolic disturbances. Here, I describe the purification of recombinant LCAT and …

    ucl Repository record

  20. The regulation of blood coagulation by high-density lipoprotein particles

    Oslakovic, CeciliaDepartment of Laboratory Medicine, Lund University2010

    High-density lipoprotein (HDL) has anti-atherogenic properties and the plasma level of HDL cholesterol correlates inversely with the risk of coronary artery disease. The atheroprotective functions of HDL can be explained by its function in the reverse cholesterol transport. Blood coagulation is …

    lund Repository record

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