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Showing 1 to 10 of 10 for “"High Molecular Weight Kininogen"”.
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Elucidating the Ferritin-High Molecular Weight Kininogen Domain 5 Interaction
… as wound healing and tumor growth. It is a highly regulated process, as numerous endogenous angiogenic modulators exist that both positively and negatively control vascularization. When the balance of modulators is altered, pathologic angiogenesis can occur. One such modulator is derived …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… Bradykinin derives from the cleavage of the high molecular weight kininogen and is catabolized mainly by ACE. During acute attacks of C1-inhibitor deficiency angioedema, high levels of cleaved high molecular weight kininogen (marker of bradykinin generation) were observed, thus indicating …
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Kininogen and Ferritin in Tumorigenesis
High molecular weight kininogen (HK) is a plasma glycoprotein which serves as a cofactor in the intrinsic coagulation cascade, and it is also known as an inhibitor of cysteine proteases. HKa can interact with a variety of cells including endothelial cells, neutrophils, monocytes and platelets. When …
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Host response in sepsis
… the intensivist. Despite modern medication and high technology supportive care, mortality is high. Key strategies include to find and take care of causative agents at the infection site. Unfortunately, the microbes are sometimes “slippery small ones” protecting themselves by for example …
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Kinin System Activation in Vasculitis
The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an …
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Novel Endogenous Antimicrobial Peptides
… the heparin binding and cell-binding domain 5 of high molecular weight kininogen, a substrate in the intrinsic pathway of coagulation. Interestingly, the peptide HKH20 (His479 His498) from this domain was active in high salt, and highly resistant to degradation by various bacterial proteases. The …
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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema
… XII (FXIIa) and bradykinin (BK) release from high molecular weight kininogen (HMWK). The primary objective of this study was to screen natural products with anti-inflammatory properties for their effects on the components namely HMWK, PK, FXIIa and FXIa. Terminalia chebula fruit, Terminalia …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… inflammation and thrombosis. Kallikrein cleaves high molecular weight kininogen (HK) to liberate the potent pro-inflammatory peptide bradykinin (BK). BK upon activation of its constitutive B2 receptors on endothelial cells leads to an increase in intracellular Ca2+ level and subsequent production …
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Characterization of Prolylcarboxypeptidase Expression Pattern in Rat Cardiomyocytes in Nutrition Overload Conditions
… through bradykinin (BK) liberation from high molecular weight kininogen (HK). PK is activated to kallikrein by PRCP, implicating a role for PRCP in the coagulation pathway. The resultant kallikrein will activate FXII which in a reciprocal manner leads to the activation of FXI. Lastly, by …
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Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
… interactions of coagulation factors in a high-throughput manner utilizing photonic microring resonators. Additionally, we have investigated the binding of factor X to the tissue factor/factor VIIa complex assembled on Nanodiscs, leading to a deeper understanding of the effects of membrane …