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Showing 1 to 5 of 5 for “"High Grade Serous Carcinoma"”.
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
<p> <p>Background: High grade serous carcinoma whether ovarian, tubal or primary peritoneal, continues to be the most lethal gynecologic malignancy in the USA. Although combination chemotherapy and aggressive surgical resection has improved survival in the past decade the majority of patients still …
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The Investigation of the SKA3 Circular RNA Role in the Ovarian Cancer Progression
… cancer biology as novel biomarkers due to their high stability as well as tissue- and developmental stage-specific expression. Despite massive improvements made in treatments, ovarian cancer (OC) still is considered one of the deadliest types of gynecologic cancers. SKA3 gene is known for its …
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The development of a blood-based test of DNA methylation for the earlier detection of high-grade serous tubo-ovarian cancer
Background High grade serous carcinoma (HGSC) is the most common and most aggressive subtype of epithelial ovarian cancer (OC). The majority of patients present in the advanced stage with poor prognosis. If diagnosed in the earliest stage (stage I) survival is greatly improved; however, there is …
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The Role of Luteal Phase Fallopian Tube Epithelium in High-grade Ovarian Serous Carcinoma
… mutation carriers, at risk for tubal and ovarian high-grade serous carcinoma (SerCa), have consistently revealed occult carcinomas and putative histological cancer precursors in the distal fallopian tube epithelium (FTE), supporting the FTE as the source of SerCa. In this thesis I molecularly …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and urgently requires new therapies. Oncolytic viruses (OV) are a strong contender. OVs interact with immune components of the TME, which can be altered due to specific genetic mutations. The present study evaluates the impact of …