Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"High Glucose"”.
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Mechanisms of High Glucose-induced Decrease in β-cell Function
… is that oxidative stress plays a causal role in high glucose-induced β-cell dysfunction in vivo via pathways that involve endoplasmic reticulum (ER) stress and JNK. The model of β-cell glucotoxicity was achieved by prolonged i.v. glucose infusion (to achieve hyperglycemia). In Study 1, 48h …
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The prevention of heparanase expression in endothelial cells injured by high glucose
… and heparanase cause endothelial injury, high concentrations of glucose (30mM), mimicking hyperglycemia and optimal doses of heparinase I were used to treat cultured porcine aortic endothelial cells (PAECs). Cell injury was measured by determining live cell number and lactate dehydrogenase …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… such as diet and exercise. Chronic exposure of high glucose and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation …
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Investigating MDM2 Regulation of Endothelial Cell Angiomir Biosynthesis in Response to High Glucose Treatment
… project is to better characterize the effect of high glucose treatment on the miRNA biogenesis machinery and miRNA expression in endothelial cells. HDMECs were incubated with low (5mM) and high (30mM) glucose concentrations for 6 and 24 hours and subsequent miRNA expression was measured. My …
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Dysfunction of Pancreatic INS-1 Beta-Cells Induced by Chronic Exposure to High Glucose
… 지속적인 노출에 의해 감소된 pdx-1 프로모터 활성을 완전히 회복시키고, 세포내 glucose-6-phosphate의 축적을 촉진시키는 2-deoxy-glucose와 octanoate는 5 mM 포도당에서 프로모터 활성을 저해시키는 것으로 볼 때, 고농도 포도당의 지속적인 노출에 의해 glucose-6-phosphate의 세포내 과량 축적이 INS-1 세포에서의 pdx-1 프로모터 활성을 감소시키는 데 중요한 역할을 할 것으로 추정된다. 또한 성장과 관련된 세포주기 억제제나 ERK 저해제가 프로모터 활성을 부분적으로 …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… of pancreatic beta cells to excessive levels of glucose and fatty acids is postulated to contribute to beta cell dysfunction and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the production of …
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The impact of high and intermittent-high glucose on ROS generation and bioenergetic metabolism in vascular endothelial cells
… disease (CVD). In vitro treatment with high glucose is known to increase ROS production in endothelial cells. However, the comparative effect of intermittent-high glucose on ROS production in endothelial cells is yet to be fully established. Moreover, the source(s) and mechanism(s) of …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
"차 례 국문요약 ⅰ 차례 iii 그림 차례 ⅵ 표 차례 ⅷ Ⅰ. 서론 1 A. 당뇨병 (Diabetes Mellitus) 1 1. 당뇨병의 정의 1 2. 당뇨병 발병 원인과 베타세포 양적 조절 1 3. 포도당/지방산 독성 (Glucolipotoxicity) 2 B. 고농도 포도당과 지방산이 INS-1 베타세포에 미치는 영향 2 1. 대사관점 2 2. 유전자 발현 2 3. 신호 전달 3 C. 고농도 포도당과 지방산에 의한 IRS-1 tyrosine 기 감소의 원인 4 1. IR (insulin receptor) 에 의한 IRS-1 …
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Expression and Regulation of Osteopontin in the Diabetic Heart
… OPN is increased in cardiac cells in response to high glucose. The hypotheses of the project are that OPN expression is increased in the type 2 diabetic heart, cardiac cells contribute to the increased OPN expression in the heart, and high glucose increases OPN expression in cardiac cells. Our …
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ADP regulation of insulin secretion and beta-cell apoptosis
… pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… for 72 hours in either baseline (25mM) or high glucose (50mM) media or with the pro-oxidant hydrogen peroxide (100μM). Changes in EB morphology and beating characteristics were observed using transmitted light microscopy. Immunocytochemistry and fluorescence microscopy imaging was used to …
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The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
Increased levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment of a person with diabetes. Angiogenesis is central …
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Development and Characterization of Tissue Engineered Blood Vessel Mimics Under "Diabetic" Conditions
… a diabetic blood vessel mimic by implementing a high glucose environment for culturing human endothelial cells from healthy umbilical veins (HUVECs) and from diabetic coronary arteries (DHCAECs). The characterization of these BVMs was achieved using immunofluorescence, scanning electron …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… of corneal and conjunctival infections and higher prevalence of dry eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may underlie these diabetes-associated ocular surface defects. Therefore, the present study was designed to …
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Taurine depletion and Schwann cell dysfunction in diabetic neuropathy
… are not well understood. Schwann cells are highly vulnerable to hyperglycaemia-induced stress which plays a key role in the pathogenesis of diabetic neuropathy, however, the mechanisms behind these effects are not well understood. In these studies I have elucidated the effect of …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
Pancreatic beta-cells may balance glucose-stimulated insulin synthesis and secretion with the proteasome activity to regulate protein concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding …
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