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Showing 1 to 20 of 28 for “"High Fat Feeding"”.
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
Skeletal muscle is highly involved in macronutrient metabolism. To maintain proper energy metabolism and physiology, skeletal muscle must adapt to nutrient supply. Thus, diet macronutrient composition is an important modulator of skeletal muscle metabolism. Evidence from rodent and human models …
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Maternal High Fat Feeding: Impact of Female Offspring Body Composition and Bone Health
High fat diet (HFD) consumption in rodents alters body composition and weakens bones. Whether female offspring of mothers consuming a HFD are similarly affected at weaning and early adulthood is unclear. This research determined whether maternal HFD contributes to long-lasting alterations in body …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… a hindered ability to properly transition from fat oxidation while in a fasted state to carbohydrate oxidation once fed, leading to a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial …
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Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… to contribute toward insulin resistance. High-fat diets reduce human skeletal muscle insulin sensitivity and mitochondrial function. Conversely, endurance training increases insulin sensitivity and enhances mitochondrial performance. Recent evidence in mice has found that central …
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The Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding
… through the administration of probiotics during high fat feeding has been shown to attenuate weight gain and body fat accretion while improving insulin sensitivity in animal models. Objective: Our objective was to determine the effects of the probiotic VSL#3 on body weightand composition, …
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Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
… of C57BL/6J mice were fed either a control low-fat diet, a control high-fat diet, or a high-fat diet supplemented with 25 mg/kg*BW of cocoa extract or one of the three cocoa fractions. After 12 weeks on these diets, the oligomer-rich fraction proved to be most effective in preventing weight …
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Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
… of CVD. Experimental evidence suggests that high fat feeding alters the functional composition of the gut microbiota (dysbiosis); leading to increased translocation of the pro-inflammatory, endotoxin, and increased production of the pro-atherogenic, trimethylamine-N-oxide (TMAO). Together, …
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Altering Muscle Hypertrophy and Fat Accumulation in Myostatin Null Mice
… wide-spread hypermuscularity and decreased fat accumulation. Though the phenotype of myostatin mutant animals is very striking, the question remains whether the loss of myostatin function fundamentally changes growth potential, metabolism, or inherent regulation in tissues, or if it is …
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The role of PYY in regulating energy balance and glucose homeostasis
… mice (PYY-/-) and PYY transgenic mice (PYYtg) highlight that PYY indeed has an important role in regulating energy balance and glucose homeostasis in vivo. PYY knockout mice became obese with ageing or high-fat feeding linked to a hyperinsulinemic phenotype associated with hypersecretion of …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… hypertension and insulin resistance. Models of high-fat feeding induce obesity, hypertension and insulin resistance and are thus used extensively to study hypertension because these models closely mimic some of the renal and cardiovascular changes found in human hypertensive pati ents. The …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… (WA) that can comprise up to 25% of total fat cells in abdominal fat pads following 8 weeks of high fat feeding. PDGFRA+ cells isolated by fluorescence-activated cell sorting differentiated into both BA and WA in vitro, and generated WA after transplantation in vivo, confirming dual …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
High-fat diets and obesity have been linked to unfavorable changes in gut bacteria and increased leakage of bacterially-derived lipopolysaccharide (endotoxin) from the intestinal tract into circulation, which is associated with low-grade inflammation, metabolic dysregulation and degradation of …
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… to baseline levels in the post-absorptive state. High-fat feeding in these animals altered these fluctuations causing endotoxin levels to remain high throughout the day. The effects of alterations in endotoxin levels on glucose metabolism are not understood. The goal of this study was to determine …
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FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance
Fatty Acid Desaturase 2 (FADS2) haplotypes associated with hyperactivity of its gene product, delta-6-desaturase (D6D), are associated with obesity and type-2 diabetes in humans. D6D regulates long-chain polyunsaturated fatty acid (PUFA) biosynthesis and is upregulated in several rodent models of …
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Investigating the physiological function of BACE1 and its role in metabolism
… metabolic dysfunction as a result of chronic high-fat feeding leads to changes in BACE1 activity, thereby increasing the susceptibility of developing AD. To do this, proteomic analysis of hippocampal and hypothalamic tissues from chow fed and high-fat fed mice were compared alongside a BACE1 …
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Ghrelin: The Hunger Hormone that Isn't
… become obese and hyperinsulinemic in response to high fat feeding. To investigate why ghrelin seems to be sufficient but not necessary for hunger, we injected increasing doses of ghrelin and measured both food intake and the resulting plasma concentration. We found that the threshold dose for an …
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Epigenetics, a signal sensor of dietary components, is involved in the hepatic gene regulation
… disease and metabolic disorder [3]. Sustained high fat feeding leads to obesity and metabolic syndrome, accompanied by low-grade inflammation, insulin resistance, and dyslipidemia. In general, the prevalence of an inflammatory response is highly associated with obesity incidence, cardiovascular …
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PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS
… serious health problem worldwide. Consumption of fat rich food is a common cause of obesity. Some of the food components (i.e. saturated free fatty acids (SFAs)) have been identified as inflammatory inducers (Egger G at al., 2010). After a meal, absorbed free fatty acids (FFAs) will be stored in …
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Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography
… Dawley rats were rendered insulin resistant by high fat feeding and diabetic by a single dose of streptozotocin (STZ). Diabetic rats were treated for 8 weeks with insulin, metformin or rosiglitazone, starting from either 1 week (prevention) or 8 weeks (reversal) after STZ administration. …
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