Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"HiF-2"”.
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… α (alpha) subunit of Hypoxia inducible factors (HIF-1alpha and HIF-2 alpha). HIF-1 alpha and HIF-2 alpha have similar structural organization, and after forming an obligate heterodimer with the common partner ARNT/HIF-1 alpha, bind to the same recognition element located in target gene promoter …
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Hypoxia regulated pathways in urological malignancies
… elucidated. Hypoxia inducible factor isoforms, HIF-1 and<br/>HIF-2, are constitutively expressed in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target genes, although their expression in …
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A Fragile Native State Structure: An Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Variant Exhibits Slow Interconversion Kinetics Between two Different Folds
… sensor PAS proteins. As part of a study of the HIF-2 alpha and ARNT PAS-B heterodimer, site-directed mutagenesis was performed on the ARNT PAS-B domain. Interestingly, one point mutation on the ARNT beta-sheet surface (Y456T) resulted in a new conformation of the domain that existed in equimolar …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… hypoxia, tumor cells induce a transcriptional shift which is mainly regulated by the transcription factors hypoxia-inducible factor (HIF)-1 and HIF-2. HIF proteins consist of two subunits, an oxygen-regulated α-subunit and a constitutively expressed β-subunit. Previous reports have shown that …
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SMAD2, SMAD3 et SARA : des facteurs clés de la signalisation du TGFβ impliqués dans l’invasion des cellules cancéreuses stimulée par le microenvironnement hypoxique
… le plus fortement régulé en hypoxie, soit HIF, dans l’invasion des cellules cancéreuses. Nous démontrons que la modulation de la stabilité ou de l’expression de HIF-1 et HIF-2 n’affecte pas la production d’invadopodes ni la capacité des cellules à migrer à l’intérieur d’une matrice de …
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Hypoxia signalling regulates human lung epithelial cell fates
… hillock-like cells. Hypoxia-inducible factors (HIFs) are the central regulators mediating cellular response to hypoxia. I found that the HIF pathway was rapidly activated upon exposure to hypoxia with a genetic HIF-DNA binding reporter. Chemical stabilisation of HIF-α subunits (HIF-1α and …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, invasion, metastasis and resistance to …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out to explore the impact of hypoxia on mammary epithelial differentiation and what consequences the hypoxic response might have on breast cancer development and behavior. We found that …
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Molecular mecanisms involved in the pathogenesis of head and neck paragangliomas
… los perfiles de expresión de genes, miRNAs y HIF-1¿ que distinguen los HNPGLs de los PG normales. Los resultados mostraron que los HNPGLs comparten un perfil de expresión génica común que difiere del de los PG normales y es independiente de la presencia de mutación en genes SDH o de las …