Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"HiChIP"”.
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Principled Methods and Models for Deep Learning Based Functional Genomics
… genomic interactions from ChIA-PET and HiChIP data. Enabled by this work, the fourth project aims to provide a means to identify reproducible long-range genomic interactions. We continue the analysis of long-range interactions in the fifth project by performing co-enrichment analysis of …
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Dissecting The Roles of Human Smc Complexes In Transcription Regulation and Chromatin Organization
… hierarchy of 3D genome, high-resolution H3K27ac HiChIP analysis after Cohesin depletion revealed that there is a large portion of regulatory chromatin loops persist after Cohesin depletion. This is a significant finding suggesting that Cohesin is not a universal organizer of short-range …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
… of these technologies (such as 5C, CHiA-PET, HiChIP and Capture Hi-C) have detected multitudes of novel looping interactions, including connections between promoters and enhancers. The interplay between precise regulatory interactions, the higher-order chromosomal organisation, and their joint …
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SOMATIC MUTATIONS AT FRAGILE ENHANCERS OF LINEAGE- IDENTITY EPITHELIAL GENES IN BREAST CANCER.
Prior research established that double-strand breaks (DSBs) in normal mammary cells are not randomly distributed, but cluster at specific sites including gene promoters. Our lab identified paused RNA polymerase II and topoisomerase2B as key contributors to DSB formation at specific promoters, and …