Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Hey1"”.
-
Biochemische Charakterisierung der basischen Helix-Loop-Helix-Transkriptionsfaktoren Hey1 und Hey2 sowie Untersuchung ihrer Rolle während der Herz- und Gefäßentwicklung
… bei der Proteinexpressionsfilter mit markierten Hey1-Peptiden nach interagierenden Proteinen durchsucht wurden. Hierbei sind 53 Proteine isoliert worden, jedoch konnte nach eingehenderen Untersuchungen kein relevanter Bindungsspartner beschrieben werden. Für weitere Analysen unter mehr …
-
Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis
… The gene expression of angiogenic related genes HEY1 and NRARP were also altered, suggesting ATF2 involvement in the regulation of these proteins. CONCLUSION: This study shows that activation of ATF2 is essential for the negative regulation of DLL4, HEY1 and NRARP. Interestingly, activation of …
-
Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… effects were coincident with increased levels of HEY1 and HEY2, biphasic regulation of VEGFR-3, and decreased levels of VEGFR-2. Using genetic intervention of Notch signaling, we demonstrated that Notch regulates developmental sprouting lymphangiogenesis by restricting growth and sprouting of …
-
Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… of Notch ligand DLL1 and Notch target gene Hey1 in VEGF-stimulated HUVEC. Expression of the transcription factor c-Fos was also elevated after PMCA4 knockdown in HUVEC stimulated with VEGF for 1h. Analysis of a gene array containing genes encoding extracellular matrix and cell adhesion …
-
Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF
… las células tip y la expresión de Notch1, Hes1, Hey1 y VEGF-A en HUVEC. Estos hallazgos se corroboraron utilizando suero de ratas sometidas a isquemia/reperfusión (I/R). Nuestros resultados muestran por primera vez la interacción funcional entre SARAF y Orai1 en las CE, remarcan el rol de las …
-
Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… reduction in the arterial markers, NOTCH, HEY1 and EPHNB2 in mutant C2 SOX17+/R140P iPSC-ECs compared to C2 SOX17+/+ cells. Additionally, two SOX17 iPSC lines, SOX17147Δ8del and SOX17145Δ18del, containing an 8bp and 18bp deletion at amino acid position 147 and 145 respectively, were …
-
3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… expression of quiescence genes Pax7, Spry1, and Hey1, whereas the aSC subpool exhibited increased expression of inflammatory and differentiation markers. Furthermore, we performed trajectory inference along the deactivation process from 2D myoblasts to qSCs and identified deactivation-associated …
-
Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… downstream Notch signaling Hes1, Hes5, and Hey1. This coincided with a significant increase in the proneural gene Mash1, suggesting that some of the machinery required for progenitor differentiation was present in cultured progenitors. In vitro results recapitulated some in vivo findings, as …